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PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits. 2020

Qi Wang, and Pingzhao Zhang, and Wei Zhang, and Xin Zhang, and Jianfeng Chen, and Peipei Ding, and Luying Li, and Xinyue Lv, and Ling Li, and Weiguo Hu
Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

UI MeSH Term Description Entries
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D011485 Protein Binding The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. Plasma Protein Binding Capacity,Binding, Protein
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071679 Glycogen Synthase Kinase 3 beta A glycogen synthase kinase-3 type enzyme that functions in ENERGY METABOLISM; EMBRYONIC DEVELOPMENT; and NEUROGENESIS. It is also involved in PROTEIN BIOSYNTHESIS and regulates cell growth and proliferation as a component of the WNT SIGNALING PATHWAY and other signaling pathways. Certain polymorphisms in the GSK3B gene have been associated with PARKINSON DISEASE; ALZHEIMER DISEASE; and BIPOLAR DISORDER. GSK-3beta,GSK3B Protein,GSK3beta,GSK 3beta
D000072278 Forkhead Box Protein M1 A forkhead box transcription factor that is expressed primarily in adult organs which contain proliferating cells such as the thymus, testis, ovary, and small intestine. It controls the expression of CELL CYCLE genes essential for DNA REPLICATION and MITOSIS, and also functions in DNA REPAIR. FOXM1 Protein
D015398 Signal Transduction The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines
D058534 Class I Phosphatidylinositol 3-Kinases A phosphatidylinositol 3-kinase subclass that includes enzymes with a specificity for 1-phosphatidylinositol, 1-phosphatidylinositol 4-phosphate, and 1-phosphatidylinositol 4,5-bisphosphate. Members of this enzyme subclass are activated by cell surface receptors and occur as heterodimers of enzymatic and regulatory subunits. Phosphatidylinositol 3-Kinase, Class I,Class I Phosphatidylinositol 3-Kinase,Class I Phosphatidylinositol 3 Kinase,Class I Phosphatidylinositol 3 Kinases,Phosphatidylinositol 3 Kinase, Class I
D058543 Class Ia Phosphatidylinositol 3-Kinase A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS. Class Ia Phosphatidylinositol 3-Kinases,Class Ia Phosphatidylinositol 3-Kinase, p110alpha Subunit,Class Ia Phosphatidylinositol 3-Kinase, p110beta Subunit,Class Ia Phosphatidylinositol 3-Kinase, p110delta Subunit,Class Ia Phosphatidylinositol 3-Kinase, p50alpha Subunit,Class Ia Phosphatidylinositol 3-Kinase, p55alpha Subunit,Class Ia Phosphatidylinositol 3-Kinase, p55gamma Subunit,Class Ia Phosphatidylinositol 3-Kinase, p85alpha Subunit,Class Ia Phosphatidylinositol 3-Kinase, p85beta Subunit,Class Ia Phosphatidylinositol 3-kinase, Regulatory, alpha Polypeptide,Class Ia Phosphatidylinositol 3-kinase, Regulatory, beta Polypeptide,Class Ia Phosphatidylinositol 3-kinase, Regulatory, gamma Polypeptide,Phosphatidylinositol 3-Kinase, Class Ia,Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide,Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide,Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide,Phosphoinositide-3-Kinase, Regulatory Subunit 1,Phosphoinositide-3-Kinase, Regulatory Subunit 2,Phosphoinositide-3-Kinase, Regulatory Subunit 3,alpha-P85 Subunit, PI-3K,p110alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase,p110beta Subunit, Class Ia Phosphatidylinositol 3-Kinase,p110delta Subunit, Class Ia Phosphatidylinositol 3-Kinase,p50alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase,p55alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase,p55gamma Subunit, Class Ia Phosphatidylinositol 3-Kinase,p85alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase,p85beta Subunit, Class Ia Phosphatidylinositol 3-Kinase,Class Ia Phosphatidylinositol 3 Kinase,Class Ia Phosphatidylinositol 3 Kinase, p110alpha Subunit,Class Ia Phosphatidylinositol 3 Kinase, p110beta Subunit,Class Ia Phosphatidylinositol 3 Kinase, p110delta Subunit,Class Ia Phosphatidylinositol 3 Kinase, p50alpha Subunit,Class Ia Phosphatidylinositol 3 Kinase, p55alpha Subunit,Class Ia Phosphatidylinositol 3 Kinase, p55gamma Subunit,Class Ia Phosphatidylinositol 3 Kinase, p85alpha Subunit,Class Ia Phosphatidylinositol 3 Kinase, p85beta Subunit,Class Ia Phosphatidylinositol 3 Kinases,PI-3K alpha-P85 Subunit,Phosphatidylinositol 3 Kinase, Class Ia,Phosphoinositide 3 Kinase, Regulatory Subunit 1,Phosphoinositide 3 Kinase, Regulatory Subunit 2,Phosphoinositide 3 Kinase, Regulatory Subunit 3,p110alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase,p110beta Subunit, Class Ia Phosphatidylinositol 3 Kinase,p110delta Subunit, Class Ia Phosphatidylinositol 3 Kinase,p50alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase,p55alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase,p55gamma Subunit, Class Ia Phosphatidylinositol 3 Kinase,p85alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase,p85beta Subunit, Class Ia Phosphatidylinositol 3 Kinase
D060066 Protein Interaction Maps Graphs representing sets of measurable, non-covalent physical contacts with specific PROTEINS in living organisms or in cells. Protein-Protein Interaction Map,Protein-Protein Interaction Network,Protein Interaction Networks,Interaction Map, Protein,Interaction Map, Protein-Protein,Interaction Network, Protein,Interaction Network, Protein-Protein,Map, Protein Interaction,Map, Protein-Protein Interaction,Network, Protein Interaction,Network, Protein-Protein Interaction,Protein Interaction Map,Protein Interaction Network,Protein Protein Interaction Map,Protein Protein Interaction Network,Protein-Protein Interaction Maps,Protein-Protein Interaction Networks

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