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The relative number of ribosomal RNA genes of the acrocentric chromosomes in one individual was measured by counting grains after in situ hybridization of 3H-labeled human 18S rDNA to fixed metaphase chromosomes. The relative amount of ribosomal RNA gene activity of each of the same chromosomes was estimated by determining the frequency with which the chromosome's nucleolus organizer region (NOR) was silver stained, the size of the silver-stained region, and how often the chromosome was found in satellite association. Results were similar in phytohemagglutinin-stimulated T-lymphocytes, Epstein-Barr virus transformed lymphoblasts, and fibroblasts. One chromosome 21 had few gene copies and low activity. One chromosome 22 had many gene copies but low activity. Both chromosomes 14 had few gene copies but high activity. The level of expression that can be achieved by rRNA gene clusters can, therefore, be determined by factors other than the number of gene copies.
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
January 1974,
Antimicrobial agents and chemotherapy,
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
January 1982,
Advances in experimental medicine and biology,
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
January 1981,
Molecular & general genetics : MGG,
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
January 1972,
Humangenetik,
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
May 2017,
Theriogenology,
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
September 1987,
Biochimie,
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
February 1984,
Nucleic acids research,
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
September 1971,
Orvosi hetilap,
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
January 1985,
European journal of cell biology,
A de Capoa, and
M P Felli, and
A Baldini, and
M Rocchi, and
N Archidiacono, and
C Aleixandre, and
O J Miller, and
D A Miller
January 2010,
Genome biology,
