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Primary refractory multiple myeloma: a real-world experience with 85 cases. 2020
Artur Jurczyszyn, and
Anna Waszczuk-Gajda, and
Jorge J Castillo, and
Katarzyna Krawczyk, and
Martin Stork, and
Ludek Pour, and
Lidia Usnarska-Zubkiewicz, and
Stanisław Potoczek, and
Iwona Hus, and
Julio Davila Valls, and
Parameswaran Hari, and
Saurabh Chhabra, and
Massimo Gentile, and
Gabor Mikala, and
Gergely Varga, and
Chor Sang Chim, and
Mark Fiala, and
Ravi Vij, and
Natalia Schutz, and
Marek Rodzaj, and
Agnieszka Porowska, and
David H Vesole, and
Agnieszka Druzd-Sitek, and
Jan Walewski, and
Ajay K Nooka
Department of Hematology, Jagiellonian University Medical College, Cracow, Poland.
This study determined whether 85 patients with multiple myeloma (MM) double-refractory to primary induction therapy with triplet regimens had a homogenous prognosis. The overall response rate (ORR) after the second-line therapy was 51%. Patients who proceeded to immediate autologous stem cell transplantation (ASCT) had better ORR than those who received conventional therapies (62% vs. 31%). The ORR for patients who had ASCT directly after the frontline therapy was higher than for those treated with other regimens as the second line therapy (91% vs. 45%) and offered ASCT as the third-line therapy (91% vs. 55%). The median progression-free survival (PFS) after the second-line therapy and median overall survival were 21.6 months and 35.6 months, respectively. ASCT after the second line treatment (HR = 0.24) was an independent predictor of PFS. Eligible patients with primary refractory MM achieve the most benefit from ASCT, also performed immediately after first line induction therapy.
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