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Clinical, pharmacologic, and immunologic effects of 2'-deoxycoformycin (dCF) were evaluated in 15 patients with advanced malignancies. Toxicity was less severe with a low dose (4 mg/m2) of dCF, but this dose still resulted in suppression of cellular adenosine deaminase activity, skin test reactivity, and lymphocyte responses to mitogens. Improvement in cutaneous T cell lymphoma plaques was seen after dCF. Further investigations of antitumor efficacy with the use of this low dosage schedule should continue in patients with hematologic neoplasms, and additional preliminary studies of the combination of an adenosine deaminase inhibitor with an adenosine analog should also be considered.
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
December 1996,
Hematology and cell therapy,
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
October 1973,
Bollettino chimico farmaceutico,
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
June 1981,
Cancer research,
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
August 1979,
Cancer research,
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
July 1981,
Blood,
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
January 1980,
Cancer chemotherapy and pharmacology,
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
October 1980,
Biochemical pharmacology,
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
April 1968,
Archives internationales de pharmacodynamie et de therapie,
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
September 1989,
Bone marrow transplantation,
F J Cummings, and
G W Crabtree, and
M C Wiemann, and
E N Spremulli, and
R E Parks, and
P Calabresi
January 1986,
Zeitschrift fur arztliche Fortbildung,
