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1,2,3-Triazole β-lactam conjugates as antimicrobial agents. 2020
Rajneesh Kaur, and
Raman Singh, and
Antresh Kumar, and
Satvinder Kaur, and
Nitesh Priyadarshi, and
Nitin Kumar Singhal, and
Kuldeep Singh
Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, 133207, India.
A convenient and efficient synthesis of new triazole β-lactam conjugates using click chemistry is described. β-lactam 15 and 16 were prepared using cycloaddition strategy and propargylated at N-1 to afford compounds 17 and 18. Cu-catalyzed click reaction of these β-lactams 17 and 18 with different aryl azides provided 1,2,3-triazole conjugates 6 and 7, respectively. The products were fully characterized spectroscopically and tested against Gram-(+) and Gram-(-) bacteria. Compound 7a and 7c were found to be most active.
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