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The purpose of this study was to determine whether plasma levels of the vitamin D hormone and parathyroid hormone (PTH), two potent activators of bone remodeling sites, were altered in four astronauts during the 8-day (d) Spacelab 2 mission (SL2). Increased circulating levels of either hormone could change calcium homeostasis and bone cell activity and, thus, contribute to bone loss in crewmembers in space. The vitamin D hormone was elevated in all astronauts at the end of the first inflight day but returned to normal by the seventh day. Biologically active PTH tended to be normal throughout the mission. Both hormones were within the normal range by the end of the 8-d flight of this SL2 crew. Plasma levels of 25OHD, 24,25(OH)2D, calcium, phosphorus, and albumin were essentially normal during the mission.
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
January 2023,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
May 2022,
Children (Basel, Switzerland),
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
November 1980,
The American journal of physiology,
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
January 1995,
Mineral and electrolyte metabolism,
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
January 1990,
Clinical therapeutics,
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
December 2009,
Atherosclerosis,
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
December 1986,
Bone and mineral,
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
April 1986,
European journal of pediatrics,
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
April 1966,
The Yale journal of biology and medicine,
E R Morey-Holton, and
H K Schnoes, and
H F DeLuca, and
M E Phelps, and
R F Klein, and
R H Nissenson, and
C D Arnaud
April 1963,
Journal of chronic diseases,
