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We describe the effect of splenic irradiation (SI) (0.5-1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL). Using specific cellular characteristics we could distinguish normal from abnormal cells. The irradiation resulted in a decrease of lymph node size, reduction in spleen volume and decrease in peripheral blood lymphocytes. The one exception was a patient with a prolymphocytoid transformation of B-CLL. For 3 patients SI had to be interrupted or stopped because of severe cytopenia. Quantitation of malignant B cells and normal T lymphocytes revealed that the total irradiation dose which resulted in a specific decrease of malignant lymphocytes varied from patient to patient. Normal T-cell subpopulations, which were increased before SI, decreased to normal or abnormally low values during SI. In previously untreated patients, natural killer (NK) cell numbers decreased more rapidly than T-cell subpopulations. For 2 patients refractory to chemotherapy an increase of NK cells was observed upon SI.
L W Terstappen, and
B G de Grooth, and
W van Berkel, and
C H ten Napel, and
M van Reijn, and
J Greve
February 1976,
Blood,
L W Terstappen, and
B G de Grooth, and
W van Berkel, and
C H ten Napel, and
M van Reijn, and
J Greve
April 1991,
European journal of haematology,
L W Terstappen, and
B G de Grooth, and
W van Berkel, and
C H ten Napel, and
M van Reijn, and
J Greve
May 1978,
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L W Terstappen, and
B G de Grooth, and
W van Berkel, and
C H ten Napel, and
M van Reijn, and
J Greve
December 1974,
Cancer,
L W Terstappen, and
B G de Grooth, and
W van Berkel, and
C H ten Napel, and
M van Reijn, and
J Greve
January 1968,
Journal de radiologie, d'electrologie, et de medecine nucleaire,
L W Terstappen, and
B G de Grooth, and
W van Berkel, and
C H ten Napel, and
M van Reijn, and
J Greve
June 1975,
Cancer,
L W Terstappen, and
B G de Grooth, and
W van Berkel, and
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M van Reijn, and
J Greve
September 1975,
Cancer,
L W Terstappen, and
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M van Reijn, and
J Greve
October 1987,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
L W Terstappen, and
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J Greve
January 1989,
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L W Terstappen, and
B G de Grooth, and
W van Berkel, and
C H ten Napel, and
M van Reijn, and
J Greve
January 1978,
Zeitschrift fur Immunitatsforschung. Immunobiology,
