BIOMAT Database Logo BIOMAT Database Logo

Low Fraction Size Re-irradiation for Large Volume Recurrence of Glial Tumours. 2020

Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
Department of Oncotherapy, University of Szeged, Korányi fasor 12, Szeged, H-6720, Hungary. dobiagnes@gmail.com.

The aim of the present study was to evaluate the efficacy of re-irradiation (re-RT) in patients with advanced local relapses of glial tumours and to define the factors influencing the result of the hyper-fractionated external beam therapy on progression after primary management. We have analysed the data of 55 patients with brain tumours (GBM: 28) on progression, who were re-irradiated between January 2007 and December 2018. The mean volume of the recurrent tumour was 118 cm3, and the mean planning target volume (PTV) was 316 cm3, to which 32 Gy was delivered in 20 fractions at least 7.7 months after the first radiotherapy, using 3D conformal radiotherapy (CRT) or intensity modulated radiotherapy (IMRT). The median overall survival (mOS) from the re-RT was 8.4 months, and the 6-month and the 12-month OS rate was 64% and 31%, respectively. The most important factors by univariate analysis, which significantly improved the outcome of re-RT were the longer time interval between the diagnosis and second radiotherapy (p = 0.029), the lower histology grade (p = 0.034), volume of the recurrent tumour (p = 0.006) and Karnofsky performance status (KPS) (p = 0.009) at the re-irradiation. Our low fraction size re-irradiation ≥ 8 months after the first radiotherapy proved to be safe and beneficial for patients with large volume recurrent glial tumours.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011879 Radiotherapy Dosage The total amount of radiation absorbed by tissues as a result of radiotherapy. Dosage, Radiotherapy,Dosages, Radiotherapy,Radiotherapy Dosages
D001932 Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. Brain Cancer,Brain Metastases,Brain Tumors,Cancer of Brain,Malignant Primary Brain Tumors,Neoplasms, Intracranial,Benign Neoplasms, Brain,Brain Neoplasm, Primary,Brain Neoplasms, Benign,Brain Neoplasms, Malignant,Brain Neoplasms, Malignant, Primary,Brain Neoplasms, Primary Malignant,Brain Tumor, Primary,Brain Tumor, Recurrent,Cancer of the Brain,Intracranial Neoplasms,Malignant Neoplasms, Brain,Malignant Primary Brain Neoplasms,Neoplasms, Brain,Neoplasms, Brain, Benign,Neoplasms, Brain, Malignant,Neoplasms, Brain, Primary,Primary Brain Neoplasms,Primary Malignant Brain Neoplasms,Primary Malignant Brain Tumors,Benign Brain Neoplasm,Benign Brain Neoplasms,Benign Neoplasm, Brain,Brain Benign Neoplasm,Brain Benign Neoplasms,Brain Cancers,Brain Malignant Neoplasm,Brain Malignant Neoplasms,Brain Metastase,Brain Neoplasm,Brain Neoplasm, Benign,Brain Neoplasm, Malignant,Brain Neoplasms, Primary,Brain Tumor,Brain Tumors, Recurrent,Cancer, Brain,Intracranial Neoplasm,Malignant Brain Neoplasm,Malignant Brain Neoplasms,Malignant Neoplasm, Brain,Neoplasm, Brain,Neoplasm, Intracranial,Primary Brain Neoplasm,Primary Brain Tumor,Primary Brain Tumors,Recurrent Brain Tumor,Recurrent Brain Tumors,Tumor, Brain
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D005910 Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) Glial Cell Tumors,Malignant Glioma,Mixed Glioma,Glial Cell Tumor,Glioma, Malignant,Glioma, Mixed,Gliomas,Gliomas, Malignant,Gliomas, Mixed,Malignant Gliomas,Mixed Gliomas,Tumor, Glial Cell,Tumors, Glial Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
[Contraindications for large-fraction irradiation in malignant glial tumors].
August 1985, Meditsinskaia radiologiia,
Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
Re-irradiation for Paediatric Tumours.
March 2019, Clinical oncology (Royal College of Radiologists (Great Britain)),
Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
[Low-grade glial tumours].
June 2004, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie,
Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
Large volume re-irradiation for recurrent meningioma with pulsed reduced dose rate radiotherapy.
January 2019, Journal of neuro-oncology,
Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
Posttreatment recurrence of malignant brain neoplasm: accuracy of relative cerebral blood volume fraction in discriminating low from high malignant histologic volume fraction.
March 2009, Radiology,
Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
Re-irradiation with stereotactic radiotherapy for recurrent high-grade glial tumors.
January 2023, Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology,
Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
The role of large volume re-irradiation with Bevacizumab in chemorefractory high grade glioma.
May 2020, Clinical and translational radiation oncology,
Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
Re-irradiation of brain tumours--evidence, indications and limitations.
September 2009, European journal of cancer (Oxford, England : 1990),
Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
Results of re-irradiation for pelvic recurrence in anorectal cancer patients.
May 2019, The British journal of radiology,
Ágnes Dobi, and Barbara Darázs, and Emese Fodor, and Adrienne Cserháti, and Zsófia Együd, and Anikó Maráz, and Szilvia László, and Leopold Dodd, and Zita Reisz, and Pál Barzó, and Judit Oláh, and Katalin Hideghéty
Two Cases of Ovariotomy for Tumours of Unusually Large Size.
May 1906, The Indian medical gazette,
Copied contents to your clipboard!