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Don't forget ototoxicity during the SARS-CoV-2 (Covid-19) pandemic! 2020

Andrea Ciorba, and Virginia Corazzi, and Piotr Henryk Skarżyński, and Magdalena B Skarżyńska, and Chiara Bianchini, and Stefano Pelucchi, and Stavros Hatzopoulos
ENT & Audiology Department, University Hospital of Ferrara, Ferrara, Italy.

Aim of this communication is to remind clinical professionals to be aware of ototoxic side effects of several specific drugs proposed for the treatment of the new virus SARS-CoV-2 (Covid-19). In particular, chloroquine and hydroxychloroquine, azithromycin, as well as antiviral drugs such as remdesivir, favipiravir and lopinavir can all present potential ototoxic side effects. The data in the literature do not offer specific information on their potential synergetic effects nor on their interactions.

UI MeSH Term Description Entries
D011024 Pneumonia, Viral Inflammation of the lung parenchyma that is caused by a viral infection. Pneumonias, Viral,Viral Pneumonia,Viral Pneumonias
D006311 Hearing Disorders Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices, including the sensorineural pathways. Distorted Hearing,Dysacusis,Paracousis,Paracusis,Hearing Disorder,Hearing, Distorted
D006320 Hearing Tests Part of an ear examination that measures the ability of sound to reach the brain. Hearing in Noise Test,Quick Speech-in Noise Test (QuickSIN),Real Ear Measurement,Speech in Noise Hearing Test,Ear Measurement, Real,Ear Measurements, Real,Hearing Test,Measurement, Real Ear,Measurements, Real Ear,Quick Speech in Noise Test (QuickSIN),Real Ear Measurements,Test, Hearing,Tests, Hearing
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000081015 Ototoxicity Damage to the EAR or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION. Auditory Toxicity,Drug-Induced Cochlear Toxicity,Drug-Induced Cochleotoxicity,Drug-Induced Otological Toxicity,Drug-Induced Ototoxicity,Drug-Induced Vestibular Toxicity,Drug-Induced Vestibulotoxicity,Drug-Related Cochlear Toxicity,Drug-Related Cochleotoxicity,Drug-Related Otological Toxicity,Drug-Related Ototoxicity,Otological Toxicity,Radiation-Induced Ototoxicity,Cochlear Toxicities, Drug-Induced,Cochlear Toxicities, Drug-Related,Cochlear Toxicity, Drug-Induced,Cochlear Toxicity, Drug-Related,Cochleotoxicities, Drug-Induced,Cochleotoxicities, Drug-Related,Cochleotoxicity, Drug-Induced,Cochleotoxicity, Drug-Related,Drug Induced Cochlear Toxicity,Drug Induced Cochleotoxicity,Drug Induced Otological Toxicity,Drug Induced Ototoxicity,Drug Induced Vestibular Toxicity,Drug Induced Vestibulotoxicity,Drug Related Cochlear Toxicity,Drug Related Cochleotoxicity,Drug Related Otological Toxicity,Drug Related Ototoxicity,Drug-Induced Cochlear Toxicities,Drug-Induced Cochleotoxicities,Drug-Induced Otological Toxicities,Drug-Induced Ototoxicities,Drug-Induced Vestibular Toxicities,Drug-Induced Vestibulotoxicities,Drug-Related Cochlear Toxicities,Drug-Related Cochleotoxicities,Drug-Related Otological Toxicities,Drug-Related Ototoxicities,Otological Toxicities, Drug-Induced,Otological Toxicities, Drug-Related,Otological Toxicity, Drug-Induced,Otological Toxicity, Drug-Related,Ototoxicities,Ototoxicities, Drug-Induced,Ototoxicities, Drug-Related,Ototoxicities, Radiation-Induced,Ototoxicity, Drug-Induced,Ototoxicity, Drug-Related,Ototoxicity, Radiation-Induced,Radiation Induced Ototoxicity,Radiation-Induced Ototoxicities,Toxicity, Otological,Vestibular Toxicities, Drug-Induced,Vestibular Toxicity, Drug-Induced,Vestibulotoxicities, Drug-Induced,Vestibulotoxicity, Drug-Induced
D000086382 COVID-19 A viral disorder generally characterized by high FEVER; COUGH; DYSPNEA; CHILLS; PERSISTENT TREMOR; MUSCLE PAIN; HEADACHE; SORE THROAT; a new loss of taste and/or smell (see AGEUSIA and ANOSMIA) and other symptoms of a VIRAL PNEUMONIA. In severe cases, a myriad of coagulopathy associated symptoms often correlating with COVID-19 severity is seen (e.g., BLOOD COAGULATION; THROMBOSIS; ACUTE RESPIRATORY DISTRESS SYNDROME; SEIZURES; HEART ATTACK; STROKE; multiple CEREBRAL INFARCTIONS; KIDNEY FAILURE; catastrophic ANTIPHOSPHOLIPID ANTIBODY SYNDROME and/or DISSEMINATED INTRAVASCULAR COAGULATION). In younger patients, rare inflammatory syndromes are sometimes associated with COVID-19 (e.g., atypical KAWASAKI SYNDROME; TOXIC SHOCK SYNDROME; pediatric multisystem inflammatory disease; and CYTOKINE STORM SYNDROME). A coronavirus, SARS-CoV-2, in the genus BETACORONAVIRUS is the causative agent. 2019 Novel Coronavirus Disease,2019 Novel Coronavirus Infection,2019-nCoV Disease,2019-nCoV Infection,COVID-19 Pandemic,COVID-19 Pandemics,COVID-19 Virus Disease,COVID-19 Virus Infection,Coronavirus Disease 2019,Coronavirus Disease-19,SARS Coronavirus 2 Infection,SARS-CoV-2 Infection,Severe Acute Respiratory Syndrome Coronavirus 2 Infection,COVID19,2019 nCoV Disease,2019 nCoV Infection,2019-nCoV Diseases,2019-nCoV Infections,COVID 19,COVID 19 Pandemic,COVID 19 Virus Disease,COVID 19 Virus Infection,COVID-19 Virus Diseases,COVID-19 Virus Infections,Coronavirus Disease 19,Disease 2019, Coronavirus,Disease, 2019-nCoV,Disease, COVID-19 Virus,Infection, 2019-nCoV,Infection, COVID-19 Virus,Infection, SARS-CoV-2,Pandemic, COVID-19,SARS CoV 2 Infection,SARS-CoV-2 Infections,Virus Disease, COVID-19,Virus Infection, COVID-19
D000093485 COVID-19 Drug Treatment The use of DRUGS to treat COVID19 or its symptoms. COVID-19 Drug Therapy,COVID19 Drug Therapy,COVID19 Drug Treatment,Coronavirus Disease 2019 Drug Treatment,Coronavirus Disease-19 Drug Treatment,COVID 19 Drug Therapy,COVID 19 Drug Treatment,COVID-19 Drug Therapies,COVID19 Drug Therapies,COVID19 Drug Treatments,Coronavirus Disease 19 Drug Treatment,Drug Therapy, COVID-19,Drug Therapy, COVID19,Therapy, COVID-19 Drug,Therapy, COVID19 Drug,Treatment, COVID-19 Drug
D000962 Antimalarials Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) Anti-Malarial,Antimalarial,Antimalarial Agent,Antimalarial Drug,Anti-Malarials,Antimalarial Agents,Antimalarial Drugs,Agent, Antimalarial,Agents, Antimalarial,Anti Malarial,Anti Malarials,Drug, Antimalarial,Drugs, Antimalarial
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D016903 Drug Monitoring The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically. Monitoring, Drug,Therapeutic Drug Monitoring,Drug Monitoring, Therapeutic,Monitoring, Therapeutic Drug

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