-transparent.png){kind=logo}
This study was undertaken to determine if calcium status modulates calcitonin gene-related peptide (CGRP) neuronal content. In two separate experiments, young, growing rats and mature rats were placed on low, normal, and high calcium diets for four weeks. CGRP immunostaining was localized immunocytochemically in laminae I and II of the upper thoracic spinal cord in young rats and in the upper thoracic and lumbar spinal cord in mature rats. Low calcium intake decreased dorsal horn CGRP content in young, growing rats, while high calcium diet significantly increased CGRP content, as determined by computer-assisted image processing, in both young and adult rats. A significant positive correlation was found between the serum ionized calcium and CGRP content in laminae I and II. Thus, calcium balance appears to modulate neuronal CGRP content.
D J DiPette, and
K N Westlund, and
O B Holland
December 1988,
Brain research,
D J DiPette, and
K N Westlund, and
O B Holland
February 1996,
Neuroscience letters,
D J DiPette, and
K N Westlund, and
O B Holland
August 1997,
Science in China. Series C, Life sciences,
D J DiPette, and
K N Westlund, and
O B Holland
August 1996,
Pain,
D J DiPette, and
K N Westlund, and
O B Holland
September 1991,
Brain research,
D J DiPette, and
K N Westlund, and
O B Holland
October 2007,
Spinal cord,
D J DiPette, and
K N Westlund, and
O B Holland
January 1991,
Annals of the New York Academy of Sciences,
D J DiPette, and
K N Westlund, and
O B Holland
January 1990,
Neuroscience,
D J DiPette, and
K N Westlund, and
O B Holland
January 1986,
Neuroscience letters,
D J DiPette, and
K N Westlund, and
O B Holland
January 1992,
Histochemistry,
