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Low molecular weight IgM, the monomeric subunit of pentameric IgM, was clearly detected by immunoblotting and filtration chromatographic techniques in six patients with juvenile chronic arthritis and in trace quantities in a further eight of 24 patients studied. This low molecular weight IgM moiety contributed up to 33% of the total circulating IgM and was strongly associated with raised serum concentrations of IgM and the presence of antinuclear antibodies, extractable antinuclear antibodies, and rheumatoid factor. Immunoblot analysis of positive serum samples showed small quantities of other low molecular weight oligomers of IgM in addition to monomeric IgM. It is postulated that the presence of low molecular weight IgM in the serum of patients with juvenile chronic arthritis reflects a disorder of the intracellular assembly of IgM subunits during a stimulated IgM immune response. The pathogenetic role of low molecular weight IgM remains uncertain.
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
January 1985,
Arthritis and rheumatism,
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
June 1994,
Annals of the rheumatic diseases,
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
August 1980,
Annals of the rheumatic diseases,
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
June 1981,
Arthritis and rheumatism,
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
August 1987,
The Journal of rheumatology,
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
July 1987,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
February 1969,
The Journal of laboratory and clinical medicine,
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
April 1986,
Journal of immunological methods,
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
January 1970,
Progress in immunobiological standardization,
P J Roberts-Thomson, and
K Shepherd, and
T R Southwood, and
M J Ahern, and
L Y Koh, and
J O'Donnell, and
J Ziegler, and
J Edmonds
January 1993,
Clinical and experimental rheumatology,
