Comparison of ophthalmic toxicity of light-emitting diode and organic light-emitting diode light sources. 2020

Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

The use of organic light-emitting diodes (OLEDs) has rapidly increased in recent years. However, the effect of OLEDs on human health has not been studied yet. We investigated morphologic and functional changes after OLEDs exposure of human ocular cells, including corneal, conjunctival, lens, and retinal pigment epithelial cells, and mouse eyes. In corneal and conjunctival epithelial cells, the levels of reactive oxygen species production and interleukin-8 expression after white light-emitting diodes (LED) exposure were significantly greater than those after OLED exposure. Although no gross morphologic changes of the eyelid or cornea were found in LED- or OLED-exposed mice, oxidative stress on ocular surface was significantly increased, and the outer nuclear layer (ONL) was significantly shorter in both light-treated groups than the control group. Moreover, ONL thickness was significantly lower in the LED group than the OLED group. The electroretinography response was significantly lower in light exposure group, and there was significant difference between LED- and OLED-treated mice. Although OLED exhibits certain ocular toxicity, it can be less toxic to eyes than LED. The higher blue-wavelength energy of LED light might be the reason for its higher toxicity relative to OLED.

UI MeSH Term Description Entries
D007908 Lens, Crystalline A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION. Eye Lens,Lens, Eye,Crystalline Lens
D008027 Light That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range. Light, Visible,Photoradiation,Radiation, Visible,Visible Radiation,Photoradiations,Radiations, Visible,Visible Light,Visible Radiations
D012160 Retina The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent. Ora Serrata
D003116 Color The visually perceived property of objects created by absorption or reflection of specific wavelengths of light. Colors
D003228 Conjunctiva The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball. Bulbar Conjunctiva,Palpebral Conjunctiva,Plica Semilunaris of Conjunctiva,Plicae Semilunares of Conjunctiva,Tunica Conjunctiva,Conjunctiva, Bulbar,Conjunctiva, Palpebral,Conjunctivas
D003315 Cornea The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed) Corneas
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004847 Epithelial Cells Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells. Adenomatous Epithelial Cells,Columnar Glandular Epithelial Cells,Cuboidal Glandular Epithelial Cells,Glandular Epithelial Cells,Squamous Cells,Squamous Epithelial Cells,Transitional Epithelial Cells,Adenomatous Epithelial Cell,Cell, Adenomatous Epithelial,Cell, Epithelial,Cell, Glandular Epithelial,Cell, Squamous,Cell, Squamous Epithelial,Cell, Transitional Epithelial,Cells, Adenomatous Epithelial,Cells, Epithelial,Cells, Glandular Epithelial,Cells, Squamous,Cells, Squamous Epithelial,Cells, Transitional Epithelial,Epithelial Cell,Epithelial Cell, Adenomatous,Epithelial Cell, Glandular,Epithelial Cell, Squamous,Epithelial Cell, Transitional,Epithelial Cells, Adenomatous,Epithelial Cells, Glandular,Epithelial Cells, Squamous,Epithelial Cells, Transitional,Glandular Epithelial Cell,Squamous Cell,Squamous Epithelial Cell,Transitional Epithelial Cell
D005123 Eye The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light. Eyes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
January 2016, Advanced materials (Deerfield Beach, Fla.),
Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
January 2010, Advanced materials (Deerfield Beach, Fla.),
Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
November 2014, Journal of nanoscience and nanotechnology,
Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
February 2020, ACS applied materials & interfaces,
Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
May 2017, Journal of biomedical optics,
Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
January 2022, Science advances,
Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
May 2014, Journal of nanoscience and nanotechnology,
Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
November 2009, Journal of nanoscience and nanotechnology,
Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
April 2010, Lab on a chip,
Ikhyun Jun, and Soo Jung Han, and Hae-Sol Shin, and Jiyeon Kim, and Eung Kweon Kim, and Tae-Im Kim, and Sang Chul Yoon, and Kyoung Yul Seo
October 2006, Optics express,
Copied contents to your clipboard!