Biomaterial Database

[I-131-LYM-1 MoAb radioimmunotherapy and LYM-1 MoAb immunotherapy in implanted nude mice model]. 1988

K Y Chen

Nuclear Medicine Section, First Hospital, Zhejiang University of Medical Sciences.

Experimental studies of I-131-LYM-1 MoAb radioimmunotherapy (RIT) and LYM-1 MoAb immunotherapy (IT) were performed in 23 implanted nude mice model. 1 x 10(7) human B-cell lymphoma cells (Raji Burkitt's cells) were injected subcutaneously into the thigh. Three weeks later, they were divided into four groups: Group A (N = 6), as control group; Group B (N = 5), received LYM-1 MoAb 60 micrograms, as IT group; Group C (N = 7), received I-131-LYM-1 MoAb 120 mu ci; and Group D (N = 5), received I-131-LYM-1 MoAb 240 mu ci. Radioimaging was performed on day 7,8,9 postinjection. Tumor growth after 30 days was as follows: Group A, from 0.040 +/- 0.091 CM3 to 7.638 +/- 5.925; Group B, from 0.326 +/- 0.315 to 4.498 +/- 2.572; Group C, from 0.632 +/- 0.449 to 3.330 +/- 4.875; Group D, from 0.490 +/- 0.531 to 2.352 +/- 2.188. When converted to Relative Increase of Tumor Volume (Times-X): The tumor in Group A increased 4346.19 X; in Group B 312.68 X; in Group C 15.94 X; and in Group D 8.36 X. Significant differences were noted between Groups A and B (p less than 0.05), A and C (p less than 0.025), A and D (p less than 0.025), B and C (p less than 0.025) and B and D (p less than 0.025). The difference between Group C and D was insignificant (p greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D007167	Immunotherapy	Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.	Immunotherapies
D007457	Iodine Radioisotopes	Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.	Radioisotopes, Iodine
D008223	Lymphoma	A general term for various neoplastic diseases of the lymphoid tissue.	Germinoblastoma,Lymphoma, Malignant,Reticulolymphosarcoma,Sarcoma, Germinoblastic,Germinoblastic Sarcoma,Germinoblastic Sarcomas,Germinoblastomas,Lymphomas,Lymphomas, Malignant,Malignant Lymphoma,Malignant Lymphomas,Reticulolymphosarcomas,Sarcomas, Germinoblastic
D008819	Mice, Nude	Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.	Athymic Mice,Mice, Athymic,Nude Mice,Mouse, Athymic,Mouse, Nude,Athymic Mouse,Nude Mouse
D009368	Neoplasm Transplantation	Experimental transplantation of neoplasms in laboratory animals for research purposes.	Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D011877	Radionuclide Imaging	The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.	Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000911	Antibodies, Monoclonal	Antibodies produced by a single clone of cells.	Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D000912	Antibodies, Neoplasm	Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.	Neoplasm Antibodies,Tumor Antibodies,Antibodies, Tumor
D001402	B-Lymphocytes	Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.	B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent