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DNase-I-sensitive sites have been located on the meiotic chromosomes of the mouse, Mus musculus, by the in situ DNase I nick-translation method. We find that: (1) of all the cell types studied, pachytene nuclei are the most sensitive to DNase I; (2) in diplotene the nicks occur preferentially in the vicinity of chiasmata; (3) the sex chromosomes are also sensitive to the enzyme despite their transcriptional quiescence; and (4) in the sex bivalent the nicks are primarily observed in the putative region of recombination. We conclude that, in addition to discriminating between the transcriptionally active and inactive states of chromatin, DNase I identifies recombination-specific chromatin changes in meiotic prophase.
R Raman, and
A P Singh, and
I Nanda
April 1993,
Genome,
R Raman, and
A P Singh, and
I Nanda
January 1988,
Chromosoma,
R Raman, and
A P Singh, and
I Nanda
September 1992,
Cancer genetics and cytogenetics,
R Raman, and
A P Singh, and
I Nanda
December 1997,
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology,
R Raman, and
A P Singh, and
I Nanda
January 2002,
Biotechnic & histochemistry : official publication of the Biological Stain Commission,
R Raman, and
A P Singh, and
I Nanda
September 2019,
Chromosoma,
R Raman, and
A P Singh, and
I Nanda
April 1985,
Experimental cell research,
R Raman, and
A P Singh, and
I Nanda
January 1988,
Yi chuan xue bao = Acta genetica Sinica,
R Raman, and
A P Singh, and
I Nanda
January 1986,
Cytobios,
R Raman, and
A P Singh, and
I Nanda
February 1988,
Nucleic acids research,
