BIOMAT Database Logo BIOMAT Database Logo

Creatine kinase (CK-BB) determination in cerebrospinal fluid after acute experimental head injury. 1988

D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Laboratory of Experimental Surgery and Surgical Research, University of Athens Medical School, Greece.

Early changes of the activity of enzymes such as creatine kinase in the cerebrospinal fluid (CSF) or serum are often investigated after head injuries to assess the extent of brain damage and establish a reliable prognosis. The purpose of the present study was to determine levels of creatine kinase isoenzyme CK-BB in the CSF of rats after experimental head injuries. External head injuries of different severity were inflicted on rats, immediately after which CSF was collected for isoenzyme activity determination. It was found that the levels of CK-BB were significantly elevated immediately after the head injury and that the greater the degree of external cranial injury inflicted, the higher the isoenzyme activity was. The results seem to provide evidence that CK-BB activity is an early indicator of brain damage and that its level may reflect the extent of cerebral damage involved.

UI MeSH Term Description Entries
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001930 Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. Brain Lacerations,Acute Brain Injuries,Brain Injuries, Acute,Brain Injuries, Focal,Focal Brain Injuries,Injuries, Acute Brain,Injuries, Brain,Acute Brain Injury,Brain Injury,Brain Injury, Acute,Brain Injury, Focal,Brain Laceration,Focal Brain Injury,Injuries, Focal Brain,Injury, Acute Brain,Injury, Brain,Injury, Focal Brain,Laceration, Brain,Lacerations, Brain
D003402 Creatine Kinase A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. Creatine Phosphokinase,ADP Phosphocreatine Phosphotransferase,ATP Creatine Phosphotransferase,Macro-Creatine Kinase,Creatine Phosphotransferase, ATP,Kinase, Creatine,Macro Creatine Kinase,Phosphocreatine Phosphotransferase, ADP,Phosphokinase, Creatine,Phosphotransferase, ADP Phosphocreatine,Phosphotransferase, ATP Creatine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
The diagnostic value of measuring creatine kinase BB activity in cerebrospinal fluid following acute head injury.
January 1982, Acta neurochirurgica,
D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Creatine kinase BB (CK-BB) and acute myocardial infarction.
November 1982, Clinical chemistry,
D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Cerebrospinal fluid creatine kinase-BB activity: a perspective.
November 1999, Archives of neurology,
D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Creatine kinase BB release into cerebrospinal fluid after lateral ventricle cannulation.
January 1988, British journal of neurosurgery,
D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Cerebrospinal fluid creatine kinase-BB isoenzyme activity and outcome after subarachnoid hemorrhage.
November 1999, Archives of neurology,
D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Elevation of creatine kinase BB CK in hospitalized patients. Importance of distinguishing BB CK from MB CK.
January 1982, Annals of clinical and laboratory science,
D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Problems of determining CK-BB in cerebrospinal fluid.
May 1992, Clinical chemistry,
D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Cerebrospinal fluid creatine kinase BB isoenzyme activity and neurologic prognosis after cardiac arrest.
March 1998, Neurology,
D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Cerebrospinal fluid creatine kinase BB isoenzyme activity and neurologic prognosis after cardiac arrest.
February 1997, Neurology,
D I Anagnostopoulos, and I A Dontas, and D V Kotsarelis, and G Julien, and P E Karayannacos, and C E Diakolios, and G D Skalkeas
Creatine kinase isoenzyme BB in the cerebrospinal fluid of patients with acute neurological diseases.
January 1990, Journal of internal medicine,
Copied contents to your clipboard!