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Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia. 2020
Department of Chemistry, The University of Texas at Austin, 105 E 24th St Stop A5300, Austin, TX 78712, USA. emilyque@cm.utexas.edu.
We report two highly fluorinated Cu-based imaging agents, CuL1 and CuL2, for detecting cellular hypoxia as nanoemulsion formulations. Both complexes retained their initial quenched 19F MR signals due to paramagnetic Cu2+; however, both complexes displayed a large signal increase when the complex was reduced. DLS studies showed that the CuL1 nanoemulsion (NECuL1) had a hydrodiameter of approximately 100 nm and that it was stable for four weeks post-preparation. Hypoxic cells incubated with NECuL1 showed that 40% of the Cu2+ taken up was reduced in low oxygen environments.
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