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Acromegaly is associated with abnormal indices of body composition (as determined by exchangeable sodium, exchangeable potassium and total body water estimations) which may be corrected by treatment. We related these indices of body composition to the attained growth hormone levels (mean of five daytime values) in 42 treated acromegalics. Somatomedin C was measured in 30 subjects. The mean duration of treatment was 7.7 years (range 1-26). Exchangeable sodium, potassium and total body water were significantly lowered by treatment. After treatment of acromegaly subjects whose growth hormone level was below 5 mU/l achieved normal body composition more often than those with higher levels. Growth hormone concentration of below 5 mU/l after treatment should be regarded as more appropriate index of control of acromegaly than the higher levels previously recommended.
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D L Davies
July 1988,
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A R McLellan, and
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January 1992,
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A R McLellan, and
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A R McLellan, and
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A R McLellan, and
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A R McLellan, and
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A R McLellan, and
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A R McLellan, and
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A R McLellan, and
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The Journal of clinical endocrinology and metabolism,
