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1. The effect of potassium (K) loading for 10 days on bone sodium (Na) and total exchangeable Na in sheep was examined. 2. There were no significant changes in Na space or exchangeable Na after K loading. 3. Bone Na concentration decreased by approximately 20% after K loading. 4. The degree of mobilization of Na from both the non-exchangeable and exchangeable pools in bone is sufficient to account to a large degree for the observed increase in extracellular fluid volume and the net negative sodium balance which is observed during K loading.
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