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The female sex hormone, oestrogen, plays a central role in breast cell proliferation in both the normal and malignant state. It controls transcription from several genes, including that for the progesterone receptor, and in endometrial tissue, via this receptor, it controls the gene for the enzyme oestrogen sulfotransferase. This enzyme may control the level of the oestrogen receptor by sulfurylating free oestradiol. To study the mode of transcriptional control exercised by oestrogen, bovine oestrogen sulfotransferase cDNA has been cloned and the nucleotide sequence determined. The message, of which 1812 bases have been sequenced, contains an open reading frame of 885 bases which encode a protein of 295 amino acids and a maximum apparent molecular weight of 34,600. The deduced protein sequence is supported by existing peptide sequence data and appears to contain a steroid-binding region. Some physico-chemical characteristics of the enzyme appear to differ markedly from those previously reported.
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
February 1994,
Molecular and cellular endocrinology,
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
October 1993,
Archives of biochemistry and biophysics,
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
May 1992,
Molecular pharmacology,
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
June 1994,
Chemico-biological interactions,
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
June 1990,
Nucleic acids research,
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
March 1993,
Biochemical and biophysical research communications,
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
November 1986,
Proceedings of the National Academy of Sciences of the United States of America,
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
December 1987,
Advances in dental research,
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
January 2001,
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
A R Nash, and
W K Glenn, and
S S Moore, and
J Kerr, and
A R Thompson, and
E O Thompson
January 1987,
Gene,
