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OKT3 monoclonal antibody (OKT3) has already proved to be a valuable edition to the immunosuppression armamentarium available in cardiac transplantation. It is highly effective in treating refractory rejection, where approximately 90% of subjects may be salvaged. It may be even more valuable in prophylaxis, where in combination with an antibody suppression strategy and low-dose, "delayed" cyclosporine it appears to afford near complete protection against rejection. Moreover, OKT3-based prophylaxis seems to impact favorably on the rejection rate after the prophylaxis course has been completed. Adverse reactions are common and generally manageable, although occasional serious clinical events do occur.
M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
F S Watson, and
E Hammond, and
R G Lee, and
R Menlove
January 1989,
The Journal of heart transplantation,
M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
F S Watson, and
E Hammond, and
R G Lee, and
R Menlove
January 1988,
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M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
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E Hammond, and
R G Lee, and
R Menlove
January 1993,
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M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
F S Watson, and
E Hammond, and
R G Lee, and
R Menlove
January 1991,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
F S Watson, and
E Hammond, and
R G Lee, and
R Menlove
February 1988,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
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E Hammond, and
R G Lee, and
R Menlove
September 1991,
Zeitschrift fur Gastroenterologie,
M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
F S Watson, and
E Hammond, and
R G Lee, and
R Menlove
September 1988,
Annals of surgery,
M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
F S Watson, and
E Hammond, and
R G Lee, and
R Menlove
August 1997,
The Thoracic and cardiovascular surgeon,
M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
F S Watson, and
E Hammond, and
R G Lee, and
R Menlove
January 1989,
The Journal of heart transplantation,
M R Bristow, and
E M Gilbert, and
J B O'Connell, and
D G Renlund, and
F S Watson, and
E Hammond, and
R G Lee, and
R Menlove
July 1993,
The American journal of the medical sciences,
