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The effect of graded increments in positive end-expiratory pressure (PEEP) on arterial oxygen partial pressure (PaO2) and shunt fraction (Qs/QT), oxygen delivery, and respiratory mechanics and work required to ventilate 8 critically ill patients is reported. The work required to ventilate the patients increases markedly with the application and progressive increase in the level of PEEP. However, improvement in lung mechanics lowers the net work of ventilating the lungs. At 20 cm H2O PEEP, the mean value for the work of ventilation in this group of patients is twice the mean value without PEEP. The increase in work of ventilation with PEEP is critical in the use of PEEP when patients are breathing spontaneously with or without intermittent mandatory ventilation.
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
July 1973,
Chest,
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
November 1998,
American journal of respiratory and critical care medicine,
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
April 1986,
The Journal of pediatrics,
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
January 2010,
Critical care (London, England),
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
May 1974,
Nederlands tijdschrift voor geneeskunde,
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
June 1986,
Kokyu to junkan. Respiration & circulation,
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
August 1990,
Critical care medicine,
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
August 1988,
Acta anaesthesiologica Scandinavica,
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
March 2014,
Anesthesia and analgesia,
C F Hobelmann, and
D E Smith, and
R W Virgilio, and
R M Peters
September 1973,
Annals of surgery,
