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Effect of protein kinase C activation and depletion on insulin stimulation of glycogen synthesis in cultured hepatoma cells. 1988
Laboratoire de Biochimie, INSERM U.181, Faculté de Médecine Saint-Antoine, Paris, France.
Insulin stimulation of glycogen synthesis was nearly abolished in hepatoma cells shortly treated with 4 beta-phorbol 12 beta-myristate, 13 alpha-acetate (protein kinase C activation) but remained unmodified in cells chronically treated with the phorbol ester (protein kinase C depletion). Thus, although exogenous activation of protein kinase C results in an inhibition of insulin action, protein kinase C depletion has no influence on this process. The results suggest that, in hepatoma cells, no endogenous activation of protein kinase C may occur in response to the signal triggered by insulin.
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