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Hunzeylanines A-E, Five Bisindole Alkaloids Tethered with a Methylene Group from the Roots of Hunteria zeylanica. 2020
Jian Zhang, and
Meng-Fei Yuan, and
Song-Tao Li, and
Chen-Chen Sang, and
Min-Feng Chen, and
Yun-Lin Ao, and
Zi-Wei Li, and
Jing Xie, and
Wen-Cai Ye, and
Xiao-Qi Zhang
Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, P. R. China.
Five novel bisindole alkaloids, hunzeylanines A-E (1-5), with an unprecedented skeleton were isolated from the roots of Hunteria zeylanica. Compounds 1-5 represent the first examples of akuammine-pleioarpamine-type bisindole alkaloids fused with a dihydropyran unit. Their structures including absolute configurations were established through comprehensive spectroscopic data analyses and computational calculation methods. The plausible biogenetic pathway of 1 was also proposed. Alkaloids 1 and 2 displayed moderate cytotoxicity toward three human cancer cell lines (MDA-MB-231, AV3, and Huh7).
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