An Integrated Computer-Aided Design and Manufacturing Workflow for Synthetic Biology. 2020

Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
DOE Joint Genome Institute (JGI), Berkeley, CA, USA. eoberortner@lbl.gov.

Biological computer-aided design and manufacturing (bioCAD/CAM) tools facilitate the design and build processes of engineering biological systems using iterative design-build-test-learn (DBTL) cycles. In this book chapter, we highlight some of the bioCAD/CAM tools developed and used at the US Department of Energy (DOE) Joint Genome Institute (JGI), Joint BioEnergy Institute (JBEI), and Agile BioFoundry (ABF). We demonstrate the use of these bioCAD/CAM tools on a common workflow for designing and building a multigene pathway in a hierarchical fashion. Each tool presented in this book chapter is specifically tailored to support one or more specific steps in a workflow, can be integrated with the others into design and build workflows, and can be deployed at academic, government, or commercial entities.

UI MeSH Term Description Entries
D012984 Software Sequential operating programs and data which instruct the functioning of a digital computer. Computer Programs,Computer Software,Open Source Software,Software Engineering,Software Tools,Computer Applications Software,Computer Programs and Programming,Computer Software Applications,Application, Computer Software,Applications Software, Computer,Applications Softwares, Computer,Applications, Computer Software,Computer Applications Softwares,Computer Program,Computer Software Application,Engineering, Software,Open Source Softwares,Program, Computer,Programs, Computer,Software Application, Computer,Software Applications, Computer,Software Tool,Software, Computer,Software, Computer Applications,Software, Open Source,Softwares, Computer Applications,Softwares, Open Source,Source Software, Open,Source Softwares, Open,Tool, Software,Tools, Software
D017076 Computer-Aided Design The use of computers for designing and/or manufacturing of anything, including drugs, surgical procedures, orthotics, and prosthetics. CAD-CAM,Computer-Aided Manufacturing,Computer-Assisted Design,Computer-Assisted Manufacturing,Computer Aided Design,Computer Aided Manufacturing,Computer Assisted Design,Computer Assisted Manufacturing,Computer-Aided Designs,Computer-Assisted Designs,Design, Computer-Aided,Design, Computer-Assisted,Designs, Computer-Aided,Designs, Computer-Assisted,Manufacturing, Computer-Aided,Manufacturing, Computer-Assisted
D057188 Workflow Description of pattern of recurrent functions or procedures frequently found in organizational processes, such as notification, decision, and action. Work Flow,Work Flows,Workflows
D058615 Synthetic Biology A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems. Biologies, Synthetic,Biology, Synthetic,Synthetic Biologies

Related Publications

Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
January 1999, Military medicine,
Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
July 2014, The journal of contemporary dental practice,
Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
January 2010, Evidence-based dentistry,
Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
May 2017, Neurosurgical focus,
Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
January 2022, Cureus,
Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
May 2015, The Journal of craniofacial surgery,
Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
January 2021, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons,
Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
October 2022, Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology,
Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
January 2020, International journal of bioprinting,
Ernst Oberortner, and Robert Evans, and Xianwei Meng, and Sangeeta Nath, and Hector Plahar, and Lisa Simirenko, and Angela Tarver, and Samuel Deutsch, and Nathan J Hillson, and Jan-Fang Cheng
July 1990, Clinical orthopaedics and related research,
Copied contents to your clipboard!