-transparent.png){kind=logo}
The contribution of nitro compounds to airborne particulate mutagenicity was studied with Salmonella typhimurium strains TA98, TA98NR, TA98/1,8DNP6. The results obtained indicate that nitropyrenes play a minor role in air particulate mutagenicity. Seasonal variations indicate a relatively greater contribution of nitro compounds to the mutagenicity of spring and summer samples. Fractionation of extracts into acidic, neutral and basic components shows that neutral compounds account for about two-thirds of the total mutagenic activity. Attempts to extract mutagens adsorbed onto particulate matter with aqueous media were almost completely negative. No significant mutagenicity was detected in urine and faecal extracts and in plasma samples of Sprague-Dawley rats treated with air particulate extracts at 80 mg/kg either per os or by i.p. injection. Negative results were obtained in the micronucleus test with Swiss mice treated at 200 and 400 mg/kg (twice by i.p. injection). A significant decrease in liver aminopyrine-N-demethylase was observed in Swiss mice injected with air particulate extracts or its basic and neutral fractions. In vitro experiments suggest a direct interaction of test materials with microsomal cytochrome P-450.
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
August 1993,
Mutation research,
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
March 2004,
Central European journal of public health,
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
January 1978,
Cancer letters,
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
January 1980,
Atmospheric environment,
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
January 1983,
Environmental mutagenesis,
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
January 1997,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
August 1993,
Arzneimittel-Forschung,
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
August 1999,
Mutation research,
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
January 1992,
Mutation research,
R Crebelli, and
S Fuselli, and
A Meneguz, and
G Aquilina, and
L Conti, and
P Leopardi, and
A Zijno, and
F Baris, and
A Carere
February 1983,
Mutation research,
