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Genotoxic effects of both amitraz and its metabolites made by S9 fraction were reevaluated in short-term bacterial assays. Neither amitraz nor its metabolites induced frameshift mutation or caused base-pair substitution as detected by the Ames test. They also did not introduce any damages into DNA recognized by correndonuclease II as shown by the repair test. Metabolites of amitraz (but not amitraz itself) induced the SOS-repair system in E. coli strain PQ 243 tagA, alkA which was deficient in N-glycosylases. It is concluded that neither amitraz nor its metabolites have mutagenic activity. In contrast to amitraz, its metabolites alkylate DNA in the N3-position of adenine.
B Tudek, and
J Gajewska, and
M Szczypka, and
I Rahden-Staron, and
T Szymczyk
January 1993,
Acta biochimica Polonica,
B Tudek, and
J Gajewska, and
M Szczypka, and
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T Szymczyk
January 1997,
Roczniki Panstwowego Zakladu Higieny,
B Tudek, and
J Gajewska, and
M Szczypka, and
I Rahden-Staron, and
T Szymczyk
December 1985,
Mutation research,
B Tudek, and
J Gajewska, and
M Szczypka, and
I Rahden-Staron, and
T Szymczyk
January 1987,
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement,
B Tudek, and
J Gajewska, and
M Szczypka, and
I Rahden-Staron, and
T Szymczyk
February 1988,
Mutation research,
B Tudek, and
J Gajewska, and
M Szczypka, and
I Rahden-Staron, and
T Szymczyk
January 1992,
Teratogenesis, carcinogenesis, and mutagenesis,
B Tudek, and
J Gajewska, and
M Szczypka, and
I Rahden-Staron, and
T Szymczyk
June 2016,
Cancer research,
B Tudek, and
J Gajewska, and
M Szczypka, and
I Rahden-Staron, and
T Szymczyk
January 1980,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Supplement,
B Tudek, and
J Gajewska, and
M Szczypka, and
I Rahden-Staron, and
T Szymczyk
September 1986,
Mutagenesis,
B Tudek, and
J Gajewska, and
M Szczypka, and
I Rahden-Staron, and
T Szymczyk
October 1989,
Mutation research,
