BIOMAT Database Logo BIOMAT Database Logo

Association between vitamin D/calcium intake and 25-hydroxyvitamin D and risk of ovarian cancer: a dose-response relationship meta-analysis. 2021

Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
Department of Toxicology of School of Public Health, and Department of Gynecologic Oncology of Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.

The association between vitamin D/calcium and risk of ovarian cancer is still a debatable point. The aim of our study was to systematically investigate the association between vitamin D/calcium, and the risk of ovarian cancer and estimate their dose-response association quantitatively. PubMed, EMBASE, and Web of Science databases were searched to identify relevant observational studies. Two investigators screened citations and extracted data independently. Data were extracted and the association between vitamin D/calcium and ovarian cancer risk was estimated by calculating pooled relative risks (RRs). Subgroup analyses, publication bias estimation, and dose-response analyses were carried out as well. In total, 21 articles involving 980,008 participants were included in our present study. No significant association was observed between total vitamin D intake and ovarian cancer risk (RR: 1.02; 95% CI, 0.89-1.16, p = 0.81). Further subgroup analysis suggested that neither dietary vitamin D intake (RR: 0.80; 95% CI, 0.62-1.03, p = 0.09) nor supplementary vitamin D intake (RR: 0.98; 95% CI, 0.85-1.13, p = 0.80) was associated with the risk of ovarian cancer. As for calcium, total calcium intake was found to be statistically inversely associated with ovarian cancer risk in case-control studies (RR: 0.73; 95% CI, 0.63-0.86, p < 0.001) but not in cohort studies (RR: 1.05; 95% CI, 0.90-1.24, p = 0.52). Besides, supplementation with calcium plus vitamin D was not effective for the prevention of ovarian cancer (p = 0.98). Of note, dose-response analysis based on cohort studies suggested a potential inverse U-shape relationship between calcium intake (including total calcium and dietary calcium) and ovarian cancer risk, which indicated that low dose of calcium intake might reduce ovarian cancer risk while high dose of calcium intake might not. Taken together, vitamin D could not decrease the risk of ovarian cancer. The role of calcium intake was not proven for reducing ovarian cancer risk. Besides, no evidence showed combinative use of calcium and vitamin D have additional benefits for ovarian cancer prevention.

UI MeSH Term Description Entries
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002136 Calcium, Dietary Calcium compounds in DIETARY SUPPLEMENTS or in food that supply the body with calcium. Dietary Calcium
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D014807 Vitamin D A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.

Related Publications

Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
25-Hydroxyvitamin D level, vitamin D intake, and risk of stroke: A dose-response meta-analysis.
July 2020, Clinical nutrition (Edinburgh, Scotland),
Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
Vitamin D Intake, Blood 25-Hydroxyvitamin D, and Risk of Ovarian Cancer: A Meta-Analysis of Observational Studies.
May 2023, Journal of women's health (2002),
Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
25-Hydroxyvitamin D status, vitamin D intake, and skin cancer risk: a systematic review and dose-response meta-analysis of prospective studies.
August 2020, Scientific reports,
Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose-response meta-analysis.
December 2015, Cancer causes & control : CCC,
Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake: A dose-response PRISMA meta-analysis.
September 2018, Medicine,
Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis.
September 2017, Oncotarget,
Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
Dose-response of serum 25-hydroxyvitamin D in association with risk of colorectal cancer: A meta-analysis.
April 2017, The Journal of steroid biochemistry and molecular biology,
Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk.
May 2011, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis.
April 2016, International journal of cancer,
Jiawei Xu, and Kelie Chen, and Fan Zhao, and Dongdong Huang, and Honghe Zhang, and Zhiqin Fu, and Jinming Xu, and Yongfeng Wu, and Hui Lin, and Yexinyi Zhou, and Weiguo Lu, and Yihua Wu, and Dajing Xia
Association between vitamin C intake and lung cancer: a dose-response meta-analysis.
August 2014, Scientific reports,
Copied contents to your clipboard!