-transparent.png){kind=logo}
1,2-Dimethylhydrazine is confirmed as active in the mouse bone-marrow micronucleus assay when administered as an aqueous solution via oral gavage to three different strains of mice. It is also shown to be inactive in a corresponding rat assay under similar conditions of test. The observations were independently repeated in two laboratories. In contrast, 1,2-dibromo-3-chloropropane showed the reverse profile, being active in the rat bone-marrow assay but inactive in the mouse; the latter observations were also made in two laboratories. The carcinogen procarbazine was active in both species. These findings are discussed within the context of the present GeneTox revision of the standard test protocol of the rodent bone-marrow micronucleus assay.
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
January 2004,
Report on carcinogens : carcinogen profiles,
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
January 1999,
IARC monographs on the evaluation of carcinogenic risks to humans,
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
October 1979,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans,
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
January 2011,
Report on carcinogens : carcinogen profiles,
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
January 1983,
Environmental health perspectives,
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
January 2002,
Report on carcinogens : carcinogen profiles,
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
March 1995,
Mutagenesis,
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
August 1983,
Journal of applied toxicology : JAT,
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
September 1961,
Toxicology and applied pharmacology,
R Albanese, and
E Mirkova, and
D Gatehouse, and
J Ashby
January 1991,
Environmental and molecular mutagenesis,
