Biomaterial Database

[Technical advances in demonstration of treponema-specific 19S-IgM antibodies in patients with latent or late-latent syphilis (author's transl)]. 1977

F Müller

In patients with latent or late-latent syphilis as well as neurosyphilis the demonstration of treponema-specific 19S-IgM antibodies is not regularly possible. In this publication it is shown that high IgG antibodies are the reason for a competitive IgM inhibition in the indirect immunofluorescence tests. It is demonstrated that in the above mentioned states of the infection the IgM-FTA-19S test seemed to be the method of choice to realize the existence of 19S-IgM antibodies. In sera with competitive inhibited IgM it is possible to calculate the IgM antibody activity with the aid of the socalled F factor.

UI	MeSH Term	Description	Entries
D007074	Immunoglobulin G	The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.	Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075	Immunoglobulin M	A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin.	Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D009494	Neurosyphilis	Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)	General Paresis,Juvenile Paresis,Paretic Neurosyphilis,Syphilis, Central Nervous System,Central Nervous System Syphilis,General Paralysis,General Paralysis of the Insane,General Paresis of the Insane,Neurosyphilis, Asymptomatic,Neurosyphilis, Gummatous,Neurosyphilis, Juvenile,Neurosyphilis, Secondary,Neurosyphilis, Symptomatic,Paralysis, General,Secondary Neurosyphilis,Syphilis, CNS
D005455	Fluorescent Antibody Technique	Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.	Antinuclear Antibody Test, Fluorescent,Coon's Technique,Fluorescent Antinuclear Antibody Test,Fluorescent Protein Tracing,Immunofluorescence Technique,Coon's Technic,Fluorescent Antibody Technic,Immunofluorescence,Immunofluorescence Technic,Antibody Technic, Fluorescent,Antibody Technics, Fluorescent,Antibody Technique, Fluorescent,Antibody Techniques, Fluorescent,Coon Technic,Coon Technique,Coons Technic,Coons Technique,Fluorescent Antibody Technics,Fluorescent Antibody Techniques,Fluorescent Protein Tracings,Immunofluorescence Technics,Immunofluorescence Techniques,Protein Tracing, Fluorescent,Protein Tracings, Fluorescent,Technic, Coon's,Technic, Fluorescent Antibody,Technic, Immunofluorescence,Technics, Fluorescent Antibody,Technics, Immunofluorescence,Technique, Coon's,Technique, Fluorescent Antibody,Technique, Immunofluorescence,Techniques, Fluorescent Antibody,Techniques, Immunofluorescence,Tracing, Fluorescent Protein,Tracings, Fluorescent Protein
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000907	Antibodies, Bacterial	Immunoglobulins produced in a response to BACTERIAL ANTIGENS.	Bacterial Antibodies
D001667	Binding, Competitive	The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.	Competitive Binding
D013587	Syphilis	A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.	Great Pox
D013588	Syphilis Serodiagnosis	Serologic tests for syphilis.	Kahn Test,Wassermann Reaction,Serodiagnosis, Syphilis,Reaction, Wassermann,Serodiagnoses, Syphilis,Syphilis Serodiagnoses,Test, Kahn
D014210	Treponema pallidum	The causative agent of venereal and non-venereal syphilis as well as yaws.

Related Publications

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[Quantitative determination of syphilis-specific antibodies with the 19S IgM FTA-ABS test].

January 1986, Dermatologische Monatschrift,

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[Specific antitreponemal antibodies 19 S IgM in patients with syphilis].

January 1985, Przeglad dermatologiczny,

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Treponema pallidum specific IgM haemagglutination test for serodiagnosis of syphilis.

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