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Sixty-two men who presented with previously untreated metastatic carcinoma of the prostate (D0: 10 patients; D1: 29 patients; D2: 23 patients) received oral megestrol acetate (80 mg twice daily) and minidose estrogen (diethylstibestrol 0.1 mg or ethinyl estradiol 0.05 mg once daily) as a means of achieving total androgen ablation (testicular and adrenal). A high incidence of feminizing side effects (70-74%), a higher than expected rate of cardiovascular complications (18%), an unexpected need for cortisone replacement (13%), and failure of patients with Stage D2 disease to obtain results better than those of standard therapy during the first year of observation suggest this regimen offers no advantage over other more conventional therapy.
D E Johnson, and
R J Babaian, and
D A Swanson, and
A C von Eschenbach, and
K I Wishnow, and
D Tenney
April 1981,
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D E Johnson, and
R J Babaian, and
D A Swanson, and
A C von Eschenbach, and
K I Wishnow, and
D Tenney
September 1988,
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D E Johnson, and
R J Babaian, and
D A Swanson, and
A C von Eschenbach, and
K I Wishnow, and
D Tenney
March 1981,
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D E Johnson, and
R J Babaian, and
D A Swanson, and
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K I Wishnow, and
D Tenney
April 1988,
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D E Johnson, and
R J Babaian, and
D A Swanson, and
A C von Eschenbach, and
K I Wishnow, and
D Tenney
October 1969,
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D E Johnson, and
R J Babaian, and
D A Swanson, and
A C von Eschenbach, and
K I Wishnow, and
D Tenney
September 1983,
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D E Johnson, and
R J Babaian, and
D A Swanson, and
A C von Eschenbach, and
K I Wishnow, and
D Tenney
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D E Johnson, and
R J Babaian, and
D A Swanson, and
A C von Eschenbach, and
K I Wishnow, and
D Tenney
June 1989,
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D E Johnson, and
R J Babaian, and
D A Swanson, and
A C von Eschenbach, and
K I Wishnow, and
D Tenney
April 1983,
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D E Johnson, and
R J Babaian, and
D A Swanson, and
A C von Eschenbach, and
K I Wishnow, and
D Tenney
January 1978,
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