-transparent.png){kind=logo}
One hundred five patients with peritonitis were randomized to receive either tobramycin sulfate plus clindamycin phosphate or moxalactam alone before surgical intervention. Fifty-nine patients were evaluable. A mean of 3.1 (moxalactam) and 3.5 (tobramycin-clindamycin) pathogens per patient were identified. Overall success rate was 85% (tobramycin-clindamycin, 24/30; moxalactam, 26/29). When patients with appendicitis were excluded, there was an observed but not statistically significant advantage of moxalactam over tobramycin-clindamycin (85% vs 67%). There were five deaths (tobramycin-clindamycin, four; moxalactam, one). Other complications included hypoprothrombinemia (tobramycin-clindamycin, five; moxalactam, five), renal dysfunction (tobramycin-clindamycin, three; moxalactam, one), and superinfection (tobramycin-clindamycin, nine; moxalactam, six). More wound infections were noted in the group given tobramycin-clindamycin. These data suggest that moxalactam is as safe and efficacious as tobramycin plus clindamycin. The observed benefits of this agent warrant study in a larger sample to verify advantages of moxalactam over combination therapy.
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
July 1983,
Annals of surgery,
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
September 1986,
The American surgeon,
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
September 1984,
The Journal of antimicrobial chemotherapy,
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
September 1987,
Southern medical journal,
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
June 1985,
Archives of internal medicine,
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
August 1985,
American journal of obstetrics and gynecology,
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
February 1985,
The Journal of antimicrobial chemotherapy,
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
January 1987,
Annali dell'Istituto superiore di sanita,
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
November 1981,
Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood,
T A Stellato, and
L H Danziger, and
T Hau, and
M W Gauderer, and
J L Ferron, and
N Gordon
January 1985,
Reviews of infectious diseases,
