Evans syndrome (ES) is an autoimmune condition that presents with two or more cytopenias, which includes simultaneous or sequential development of warm autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP). The association of ES with ulcerative colitis (UC) was only reported once in the literature. Herein, we present a case of a 66-year-old male patient with a history of UC, who was diagnosed with ES secondary to UC, for which he was treated with steroids. Recognizing this rare association is important as prompt treatment with intravenous immunoglobulin and steroids will improve the prognosis and reduce the risk of complications.