Biomaterial Database

AIDS-related Cryptococcus neoformans choroiditis. 2020

Gregory S Canfield, and Sarah Reingold, and Andrea Ho, and Ann D Thor, and Paula E Pecen, and Kristen DeSanto, and Daniel B Chastain, and Carlos Franco-Paredes, and Jose R Castillo-Mancilla, and Andrés F Henao-Martinez

Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, United States.

We describe a case of Cryptococcal choroiditis in a person with advanced HIV/AIDS. A 29-year-old male with AIDS presented with fever, photophobia, and ataxia secondary to cryptococcal and toxoplasma meningoencephalitis. Dilated fundoscopic examination revealed bilateral and multifocal posterior infiltrates consistent with cryptococcal choroiditis. Treatment with parenteral and intravitreal liposomal amphotericin B, oral flucytosine, and oral trimethoprim-sulfamethoxazole led to resolution of his symptoms and improvement in his vision. Our case documents a rare, intraocular opportunistic infection and highlights the importance of ophthalmologic examination in immunocompromised hosts with visual symptoms and invasive fungal infection. We discuss diagnostic and treatment considerations in cryptococcal choroiditis.