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The effects of neuromedin B (NMB), gastrin-releasing peptide (GRP)-10 and their C-terminal fragment peptides on the pancreatic and gastrointestinal hormone release were studied in dogs. Intravenous bolus injections of NMB and GRP-10 (4.5 nmol/kg) into conscious dogs elicited a sharp and statistically significant rise in plasma gastrin and insulin levels, but only GRP-10 brought on a significant rise in the plasma glucagon and enteroglucagon levels. The degree of stimulation of gastrin and insulin secretion by NMB and GRP-10 was dose-dependent. With a dose of 4.5 nmol/kg, the minimum size of C-terminal fragment peptides of NMB and GRP-10 to stimulate gastrin secretion was NMB and GRP-10, respectively. Both NMB and GRP-10 (0.1-100 nmol/l) stimulated insulin release from the isolated canine pancreas. The glucagon release was stimulated by 10 and 100 nmol/l GRP-10 and was not stimulated by the same doses of NMB. The somatostatin release was not influenced by either peptide. It is concluded that 1) NMB and GRP-10 can stimulate gastrin and pancreatic hormone secretion, and the latter effect may be mainly due to a direct action on the islet cells; 2) the stimulatory effect of GRP-10 is stronger than that of NMB. The difference in the minimal active fragment between NMB and GRP-10 suggests that the amino acid of position 3 - NMB (Leu) and GRP-10 (His) - may play an important role in their biological activity.
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
July 1983,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
September 1989,
Zeitschrift fur Gastroenterologie,
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
October 1986,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
August 1984,
The Journal of clinical endocrinology and metabolism,
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
December 1995,
Physiology & behavior,
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
January 1992,
Pancreas,
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
January 1993,
Digestion,
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
January 1996,
Peptides,
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
April 2007,
Behavioural brain research,
K Kawai, and
Y Chiba, and
H Mukai, and
E Munekata, and
K Yamashita
January 1988,
Annals of the New York Academy of Sciences,
