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Sixteen patients on long-term treatment for primary pulmonary hypertension were studied. The results were compared after a single 20 mg dose, a two-week course and long-term (13.9 months on the average) use of the drug (40 mg/day). Pulmonary arterial catheterization, thermodilution and occlusion plethysmography were used. Changes in central and peripheral hemodynamic parameters were unidirectional and similar at all stages of the study. Nifedipine improved hemodynamics, as evidenced by selected criteria, in 80% of patients exposed to acute tests, in 91% after a course of treatment and in 58% after long-term use. Therefore, considering the ability of nifedipine to improve pulmonary hemodynamics as well as stable effect over more than one year of treatment, and the absence of marked side effects, this drug can be regarded as the most effective vasodilating agent for the treatment of primary pulmonary hypertension.
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
November 1987,
Kinderarztliche Praxis,
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
January 1983,
Zeitschrift fur arztliche Fortbildung,
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
January 1988,
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR,
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
January 1989,
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna,
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
August 1984,
American heart journal,
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
April 1984,
British journal of obstetrics and gynaecology,
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
June 1983,
American heart journal,
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
May 1986,
Arquivos brasileiros de cardiologia,
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
April 1983,
American heart journal,
A Khosseĭn, and
N M Mukharliamov, and
V Iu Mareev, and
N M Lobova, and
F T Ageev
January 1990,
Zeitschrift fur Erkrankungen der Atmungsorgane,
