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Severe, acute cyanide poisoning is uncommon and can be very difficult to diagnose if a history of exposure is unavailable. Victims of smoke inhalation may have significant cyanide poisoning as well as carbon monoxide toxicity. The Lilly Cyanide Antidote Kit currently available in America unfortunately has its own inherent toxicity. An efficacious antidote lacking toxicity is desirable, especially in cases where the diagnosis of cyanide poisoning cannot be made with certainty. Hydroxycobalamin/sodium thiosulfate has been used in France since 1970. Both components have been shown to be safe and efficacious in animal studies. Case reports of human cyanide poisoning treated with hydroxycobalamin/sodium thiosulfate have been published only in French. Animal and human data on the use of this antidotal combination are reviewed. Hydroxycobalamin/sodium thiosulfate is an efficacious cyanide antidote with little inherent toxicity.
A H Hall, and
B H Rumack
January 2002,
Journal of toxicology. Clinical toxicology,
A H Hall, and
B H Rumack
August 1988,
Clinical pharmacy,
A H Hall, and
B H Rumack
March 1997,
Lakartidningen,
A H Hall, and
B H Rumack
May 1965,
Toxicology and applied pharmacology,
A H Hall, and
B H Rumack
February 1975,
Archives of toxicology,
A H Hall, and
B H Rumack
March 2022,
Clinical toxicology (Philadelphia, Pa.),
A H Hall, and
B H Rumack
January 2006,
American journal of therapeutics,
A H Hall, and
B H Rumack
June 2010,
Annals of emergency medicine,
A H Hall, and
B H Rumack
April 1945,
La Cronica medica,
A H Hall, and
B H Rumack
January 1981,
Proceedings of the Western Pharmacology Society,
