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In this study, we examined the pressure-volume (P-V) relationships of the pulmonary "venous" (P'V') system in anesthetized living dogs, and assessed compliance by fitting the derived data of the P-V relationships to the exponential function. By definition, the P'V' system consists of the pulmonary veins and the left atrium. The pulmonary "venous" volume (P'V'V) was determined with our modified double indicator dilution method using a single injection and double sampling technique. The mean left atrial pressure (PLA) was measured directly. To observe sequential changes over a wide range of the P-V relationships, dogs were studied from the control state through the volume-loaded state with dextran. The P'V'V ranged from 3.4 to 12.2 ml X kg-1 and the PLA from 3.2 to 40.6 mmHg. We fitted the data of the P-V relationships (n = 24) to the exponential function, yielding an equation: P'V'V (ml X kg-1) = 19(1-0.833(e-0.017PLA(mmHg)). We then differentiated an above equation to estimate the slope of this curve (static compliance), giving the equation: dV/dP (ml X mmHg-1 X kg-1) = 0.269(e-0.017PLA(mmHg)). Therefore, at PLA of 10 mmHg (normal level), the compliance is 0.227 ml X mmHg-1 X kg-1. The compliance, obtained with an application of the present results in dogs to man, (disregarding expected species differences), coincides well with that in man determined with our indirect method.
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
July 1965,
Journal of applied physiology,
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
December 1968,
The Journal of the American Osteopathic Association,
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
September 1965,
Experimental eye research,
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
January 1961,
Circulation research,
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
February 1979,
The Journal of surgical research,
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
January 1963,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
January 1978,
Clinical and experimental pharmacology & physiology,
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
September 1980,
Japanese circulation journal,
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
March 1974,
Circulation research,
S Hirakawa, and
M Arakawa, and
K Kambara, and
J Iinuma, and
H Miyazaki, and
T Segawa, and
M Yamaguchi
September 1983,
Anesthesiology,
