Effect of whole body gamma-radiation on glutathione reductase of rat tissues. 1987

L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma

Adult female Sprague Dawley rats approximate ten months old were exposed to whole body gamma radiation of sublethal (4 Gy) and lethal (10 Gy) doses of radiation. Serum glutathione reductase enzyme values of 4 Gy exposed rats did not show any change on first and fourth day but significantly decreased on eighth day, while enzyme values in 10 Gy exposed group remained unaltered throughout. Heart glutathione reductase activities of sublethal group did not show any change on first and eighth day but significantly decreased on fourth day. Rats exposed to lethal doses of radiation, enzyme activities remained unchanged throughout. Liver glutathione reductase enzyme values of 4 Gy exposed group showed significant decrease on first and fourth day but arrived at control values on eighth day while the same in 10 Gy exposed group showed significant decrease from first day till the eighth day. An appreciable diminution was observed in spleen glutathione reductase enzyme activities of sublethal and lethal exposed rats from first day till eighth day.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D009206 Myocardium The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D011829 Radiation Dosage The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv). Sievert Units,Dosage, Radiation,Gray Units,Gy Radiation,Sv Radiation Dose Equivalent,Dosages, Radiation,Radiation Dosages,Units, Gray,Units, Sievert
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D005260 Female Females
D005980 Glutathione Reductase Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2. Glutathione-Disulfide Reductase,Reductase, Glutathione,Reductase, Glutathione-Disulfide
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013154 Spleen An encapsulated lymphatic organ through which venous blood filters.
D014916 Whole-Body Irradiation Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms. Radiation, Whole-Body,Total Body Irradiation,Irradiation, Total Body,Irradiation, Whole-Body,Whole-Body Radiation,Irradiation, Whole Body,Irradiations, Total Body,Irradiations, Whole-Body,Radiation, Whole Body,Radiations, Whole-Body,Total Body Irradiations,Whole Body Irradiation,Whole Body Radiation,Whole-Body Irradiations,Whole-Body Radiations
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
January 1988, Radiobiologia, radiotherapia,
L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
June 1981, Biochimie,
L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
January 1982, Radiobiologiia,
L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
December 1981, Biochemical pharmacology,
L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
November 1953, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
December 1975, Radiation research,
L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
January 1952, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
March 1961, International journal of radiation biology and related studies in physics, chemistry, and medicine,
L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
April 1968, Biochimica et biophysica acta,
L R Singh, and B P Uniyal, and S K Mukherjee, and S R Sarkar, and S K Sharma
January 1952, The Journal of biological chemistry,
Copied contents to your clipboard!