-transparent.png){kind=logo}
Endothelial cells (EC) isolated from bovine brain microvessels produce a continuous monolayer when grown in primary culture. The EC are joined together by tight junctions and contain few pinocytotic vesicles. Horseradish peroxidase (HRP) is unable to penetrate this in vitro barrier system. Exposure of the cells to 1.6 M arabinose produces a reversible separation of the tight junctions with penetration of HRP across the monolayer in a pattern similar to that observed in animals after infusion of hyperosmotic solutions into the carotid artery. The behavior of brain microvascular cells in culture suggest that they retain properties important to the formation of the blood-brain barrier.
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
October 1983,
Annals of neurology,
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
June 1995,
Neurologia medico-chirurgica,
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
July 1989,
Journal of neuropathology and experimental neurology,
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
September 1995,
Brain research,
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
January 1996,
Pharmaceutical biotechnology,
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
January 1992,
NIDA research monograph,
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
April 1992,
Experimental cell research,
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
June 2022,
American journal of physiology. Regulatory, integrative and comparative physiology,
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
April 1988,
Research communications in chemical pathology and pharmacology,
K Dorovini-Zis, and
P D Bowman, and
A L Betz, and
G W Goldstein
November 2017,
Journal of microencapsulation,
