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Neuromedin-N, a novel neurotensin-like peptide, has recently been identified from porcine spinal cord by using a bioassay for a stimulatory effect on guinea pig ileum. The amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is quite homologous to the COOH-terminal sequence of neurotensin. In this study, the effect of neuromedin-N on pancreas and splanchnic blood flow was investigated in eight dogs. Intravenous injections of graded doses of synthetic neuromedin-N caused a dose-dependent decrease of systemic arterial pressure and a dose-dependent increase in both portal and superior mesenteric arterial blood flow, which were measured with transit time ultrasonic flow meter. Volume and protein output of the pancreatic juice were also increased significantly by Neuromedin-N. Pancreatic capillary blood flow measured with laser Doppler flowmetry was increased in a dose-related manner. The present study first demonstrated that neuromedin-N retains a potent stimulatory effect on the pancreas and splanchnic circulation, indicating that this peptide is one of the biological active forms of neurotensin-like peptide in mammals. This study also leads to the suggestion that this peptide possesses physiological significance as a novel neuropeptide.
S Sumi, and
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H Yajima, and
T Suzuki, and
T Tobe
January 1982,
Digestion,
S Sumi, and
K Inoue, and
M Kogire, and
R Doi, and
K Takaori, and
H Yajima, and
T Suzuki, and
T Tobe
January 1987,
Pancreas,
S Sumi, and
K Inoue, and
M Kogire, and
R Doi, and
K Takaori, and
H Yajima, and
T Suzuki, and
T Tobe
June 1985,
Life sciences,
S Sumi, and
K Inoue, and
M Kogire, and
R Doi, and
K Takaori, and
H Yajima, and
T Suzuki, and
T Tobe
July 1984,
Biochemical and biophysical research communications,
S Sumi, and
K Inoue, and
M Kogire, and
R Doi, and
K Takaori, and
H Yajima, and
T Suzuki, and
T Tobe
September 1976,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
S Sumi, and
K Inoue, and
M Kogire, and
R Doi, and
K Takaori, and
H Yajima, and
T Suzuki, and
T Tobe
July 1988,
Digestive diseases and sciences,
S Sumi, and
K Inoue, and
M Kogire, and
R Doi, and
K Takaori, and
H Yajima, and
T Suzuki, and
T Tobe
August 1983,
Digestive diseases and sciences,
S Sumi, and
K Inoue, and
M Kogire, and
R Doi, and
K Takaori, and
H Yajima, and
T Suzuki, and
T Tobe
January 1988,
Surgery, gynecology & obstetrics,
S Sumi, and
K Inoue, and
M Kogire, and
R Doi, and
K Takaori, and
H Yajima, and
T Suzuki, and
T Tobe
January 1991,
Pancreas,
S Sumi, and
K Inoue, and
M Kogire, and
R Doi, and
K Takaori, and
H Yajima, and
T Suzuki, and
T Tobe
April 1986,
Neuropeptides,
