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Cerebral blood flow and cognitive functioning in patients with disorders along the heart-brain axis: Cerebral blood flow and the heart-brain axis. 2020
Anna E Leeuwis, and
Astrid M Hooghiemstra, and
Esther E Bron, and
Sanne Kuipers, and
Eline A Oudeman, and
Tugba Kalay, and
Hans-Peter Brunner-La Rocca, and
L Jaap Kappelle, and
Robert J van Oostenbrugge, and
Jacoba P Greving, and
Wiro J Niessen, and
Mark A van Buchem, and
Matthias J P van Osch, and
Albert C van Rossum, and
Niels D Prins, and
Geert-Jan Biessels, and
Frederik Barkhof, and
, and
Wiesje M van der Flier
Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience Amsterdam UMC VU University Medical Center Amsterdam the Netherlands.
BACKGROUND We examined the role of hemodynamic dysfunction in cognition by relating cerebral blood flow (CBF), measured with arterial spin labeling (ASL), to cognitive functioning, in patients with heart failure (HF), carotid occlusive disease (COD), and patients with cognitive complaints and vascular brain injury on magnetic resonance imaging (MRI; ie, possible vascular cognitive impairment [VCI]). METHODS We included 439 participants (124 HF; 75 COD; 127 possible VCI; 113 reference participants) from the Dutch multi-center Heart-Brain Study. We used pseudo-continuous ASL to estimate whole-brain and regional partial volume-corrected CBF. Neuropsychological tests covered global cognition and four cognitive domains. RESULTS CBF values were lowest in COD, followed by VCI and HF, compared to reference participants. This did not explain cognitive impairment, as we did not find an association between CBF and cognitive functioning. CONCLUSIONS We found that reduced CBF is not the major explanatory factor underlying cognitive impairment in patients with hemodynamic dysfunction along the heart-brain axis.
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