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The distribution of cells containing messenger RNA that encodes amyloid beta protein was determined in hippocampi and in various cortical regions from cynomolgus monkeys, normal humans, and patients with Alzheimer's disease by in situ hybridization. Both 35S-labeled RNA antisense and sense probes to amyloid beta protein messenger RNA were used to ensure specific hybridization. Messenger RNA for amyloid beta protein was expressed in a subset of neurons in the prefrontal cortex from monkeys, normal humans, and patients with Alzheimer's disease. This messenger RNA was also present in the neurons of all the hippocampal fields from monkeys, normal humans and, although to a lesser extent in cornu ammonis 1, patients with Alzheimer's disease. The distribution of amyloid beta protein messenger RNA was similar to that of the neurofibrillary tangles of Alzheimer's disease in some regions, but the messenger RNA was also expressed in other neurons that are not usually involved in the pathology of Alzheimer's disease.
S Bahmanyar, and
G A Higgins, and
D Goldgaber, and
D A Lewis, and
J H Morrison, and
M C Wilson, and
S K Shankar, and
D C Gajdusek
October 1987,
Science (New York, N.Y.),
S Bahmanyar, and
G A Higgins, and
D Goldgaber, and
D A Lewis, and
J H Morrison, and
M C Wilson, and
S K Shankar, and
D C Gajdusek
December 2016,
Scientific reports,
S Bahmanyar, and
G A Higgins, and
D Goldgaber, and
D A Lewis, and
J H Morrison, and
M C Wilson, and
S K Shankar, and
D C Gajdusek
January 1988,
Alzheimer disease and associated disorders,
S Bahmanyar, and
G A Higgins, and
D Goldgaber, and
D A Lewis, and
J H Morrison, and
M C Wilson, and
S K Shankar, and
D C Gajdusek
September 1996,
Journal of the neurological sciences,
S Bahmanyar, and
G A Higgins, and
D Goldgaber, and
D A Lewis, and
J H Morrison, and
M C Wilson, and
S K Shankar, and
D C Gajdusek
April 1999,
Neuroscience,
S Bahmanyar, and
G A Higgins, and
D Goldgaber, and
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M C Wilson, and
S K Shankar, and
D C Gajdusek
January 1993,
Annals of clinical and laboratory science,
S Bahmanyar, and
G A Higgins, and
D Goldgaber, and
D A Lewis, and
J H Morrison, and
M C Wilson, and
S K Shankar, and
D C Gajdusek
December 1999,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
S Bahmanyar, and
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M C Wilson, and
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D C Gajdusek
April 1998,
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics,
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January 1993,
Acta neuropathologica,
S Bahmanyar, and
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D C Gajdusek
August 1991,
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