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Successful Treatment with Afatinib after Osimertinib-induced Interstitial Lung Disease in a Patient with EGFR-mutant Non-small-cell Lung Cancer. 2021
Shunichi Nishima, and
Akihiko Miyanaga, and
Sho Saito, and
Mizuki Yuasa, and
Satoshi Takahashi, and
Takeru Kashiwada, and
Teppei Sugano, and
Rintaro Noro, and
Yuji Minegishi, and
Yasuhiro Terasaki, and
Yoshinobu Saito, and
Kaoru Kubota, and
Masahiro Seike, and
Akihiko Gemma
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan.
Osimertinib is the standard treatment for epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer. However, drug-induced interstitial lung disease (ILD) is recognized as a serious adverse event associated with EGFR-tyrosine kinase inhibitors (TKIs). We herein report a 78-year-old woman with stage IV lung adenocarcinoma harboring an EGFR L858R mutation on exon 21 who received rechallenge treatment with afatinib after osimertinib-induced ILD with an organizing pneumonia pattern. This is the first report of successful rechallenge with afatinib after osimertinib-induced ILD. Treatment with other EGFR-TKIs after osimertinib-induced ILD may be an option for subsequent therapy.
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