A woman who recently arrived in Canada from India developed a febrile, diarrhoeal illness. Stool culture revealed the presence of Salmonella typhi, Campylobacter fetus subspecies jejuni and Shigella flexneri. Concurrent infection with these three pathogens does not appear to have been previously reported. The possibility of multiple pathogens should be considered in travellers who fail to respond to treatment of a single organism.