5-HT1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function. 2021

Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China.

Chemogenetic activation of medial vestibular nucleus-projecting 5-HT neurons resulted in deficits in vestibular-mediated tasks, including negative geotaxis, balance beam and rota-rod tests. The 5-HT1A receptor mediates the vestibular-related behavioural effects of 5-HT in the vestibular nucleus. 5-HT1A receptor activation attenuated evoked excitatory postsynaptic currents and evoked inhibitory postsynaptic currents via a presynaptic mechanism in the vestibular nucleus. While the anxiolytic effects of serotonergic neuromodulation are well studied, its role in sensorimotor coordination and postural control is unclear. In this study, we show that an increase of serotonin (5-hydroxytryptamine, 5-HT) at the medial vestibular nucleus (MVN), a brainstem centre for vestibulospinal coordination, by either direct cannula administration or chemogenetic stimulation of MVN-projecting serotonergic neurons, adversely affected performance of rats in vestibular-mediated tasks, including negative geotaxis, balance beam and rota-rod tests. Application of the 5-HT1 and 5-HT7 receptor co-agonist 8-hydroxy-2-(di-n-propylamino) tetralin recapitulated the effect of 5-HT, while co-administration of the specific 5-HT1A receptor antagonist WAY 100135 effectively abolished all 5-HT-induced behavioural deficits. This indicated that 5-HT1A receptors mediated the effects of 5-HT in the rat MVN. Using whole-cell patch-clamp recording, we demonstrated that 5-HT1A receptor activation attenuated both evoked excitatory and evoked inhibitory postsynaptic currents through a presynaptic mechanism in the rat MVN. The results thus highlight the 5-HT1A receptor as the gain controller of vestibular-related brainstem circuits for posture and balance.

UI MeSH Term Description Entries
D009435 Synaptic Transmission The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES. Neural Transmission,Neurotransmission,Transmission, Neural,Transmission, Synaptic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014726 Vestibular Nuclei The four cellular masses in the floor of the fourth ventricle giving rise to a widely dispersed special sensory system. Included is the superior, medial, inferior, and LATERAL VESTIBULAR NUCLEUS. (From Dorland, 27th ed) Schwalbe Nucleus,Vestibular Nucleus, Medial,Schwalbe's Nucleus,Medial Vestibular Nucleus,Nuclei, Vestibular,Nucleus, Medial Vestibular,Nucleus, Schwalbe,Nucleus, Schwalbe's,Schwalbes Nucleus
D017371 8-Hydroxy-2-(di-n-propylamino)tetralin A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. 8-OH-DPAT,8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide,8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (+-)-Isomer,8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (R)-Isomer,,8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (S)-Isomer,,8-Hydroxy-2-(di-n-propylamino)tetralin Hydrochloride, (R)-Isomer,,8-Hydroxy-2-(di-n-propylamino)tetralin Hydrochloride, (S)-Isomer,8-Hydroxy-2-(di-n-propylamino)tetralin, (+-)-Isomer,8-Hydroxy-2-(di-n-propylamino)tetralin, (R)-Isomer,8-Hydroxy-2-(di-n-propylamino)tetralin, (S)-Isomer
D044282 Receptor, Serotonin, 5-HT1A A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN RECEPTOR AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION. Serotonin 1A Receptor,5-HT(1A) Receptor,5-HT1A Receptor,5-Hydroxytryptamine 1A Receptor,5-Hydroxytryptamine 1A Receptors,Receptor, 5-Hydroxytryptamine 1A,Serotonin Receptor, 5-HT1A,Serotonin, 5-HT1a Receptor,1A Receptor, 5-Hydroxytryptamine,1A Receptors, 5-Hydroxytryptamine,5 HT1A Receptor,5 Hydroxytryptamine 1A Receptor,5 Hydroxytryptamine 1A Receptors,5-HT1A Serotonin Receptor,5-HT1a Receptor Serotonin,Receptor Serotonin, 5-HT1a,Receptor, 5 Hydroxytryptamine 1A,Receptor, 5-HT1A,Receptor, 5-HT1A Serotonin,Receptor, Serotonin 1A,Receptors, 5-Hydroxytryptamine 1A,Serotonin Receptor, 5 HT1A,Serotonin, 5 HT1a Receptor
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D019706 Excitatory Postsynaptic Potentials Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS. EPSP,End Plate Potentials,Excitatory Postsynaptic Currents,Current, Excitatory Postsynaptic,Currents, Excitatory Postsynaptic,End Plate Potential,Excitatory Postsynaptic Current,Excitatory Postsynaptic Potential,Plate Potential, End,Plate Potentials, End,Postsynaptic Current, Excitatory,Postsynaptic Currents, Excitatory,Postsynaptic Potential, Excitatory,Postsynaptic Potentials, Excitatory,Potential, End Plate,Potential, Excitatory Postsynaptic,Potentials, End Plate,Potentials, Excitatory Postsynaptic

Related Publications

Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
August 2003, Neuroreport,
Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
April 1994, Brain research,
Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
January 1997, Acta oto-laryngologica. Supplementum,
Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
September 1997, Neuropharmacology,
Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
May 2005, Brain research,
Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
June 1998, Neuroscience letters,
Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
November 2018, Neuroscience letters,
Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
November 1998, Neuroscience,
Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
May 1992, Annals of the New York Academy of Sciences,
Lei Han, and Kenneth Lap-Kei Wu, and Pui-Yi Kwan, and Oscar Wing-Ho Chua, and Daisy Kwok-Yan Shum, and Ying-Shing Chan
May 2019, Neuroscience,
Copied contents to your clipboard!