-transparent.png){kind=logo}
Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques. 2020
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Several HIV-1 and SIV vaccine candidates have shown partial protection against viral challenges in rhesus macaques. However, the protective efficacy of vaccine-elicited polyclonal antibodies has not previously been demonstrated in adoptive transfer studies in nonhuman primates. In this study, we show that passive transfer of purified antibodies from vaccinated macaques can protect naive animals against SIVmac251 challenges. We vaccinated 30 rhesus macaques with Ad26-SIV Env/Gag/Pol and SIV Env gp140 protein vaccines and assessed the induction of antibody responses and a putative protective signature. This signature included multiple antibody functions and correlated with upregulation of interferon pathways in vaccinated animals. Adoptive transfer of purified immunoglobulin G (IgG) from the vaccinated animals with the most robust protective signatures provided partial protection against SIVmac251 challenges in naive recipient rhesus macaques. These data demonstrate the protective efficacy of purified vaccine-elicited antiviral antibodies in this model, even in the absence of virus neutralization.
Related Publications
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
July 1995,
AIDS research and human retroviruses,
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
January 1994,
Journal of medical primatology,
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
January 1995,
AIDS (London, England),
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
March 2015,
Proceedings of the National Academy of Sciences of the United States of America,
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
June 2020,
Molecular therapy. Methods & clinical development,
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
January 2000,
Developments in biologicals,
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
October 2023,
Cell,
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
March 2021,
PLoS neglected tropical diseases,
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
April 2011,
Vaccine,
Galit Alter, and
Wen-Han Yu, and
Abishek Chandrashekar, and
Erica N Borducchi, and
Khader Ghneim, and
Ashish Sharma, and
Rebecca Nedellec, and
Katherine R McKenney, and
Caitlyn Linde, and
Thomas Broge, and
Todd J Suscovich, and
Tom Linnekin, and
Peter Abbink, and
Noe B Mercado, and
Joseph P Nkolola, and
Katherine McMahan, and
Esther A Bondzie, and
Venous Hamza, and
Lauren Peter, and
Nicole Kordana, and
Shant Mahrokhian, and
Michael S Seaman, and
Wenjun Li, and
Mark G Lewis, and
Douglas A Lauffenburger, and
Lars Hangartner, and
Rafick-Pierre Sekaly, and
Dan H Barouch
December 2012,
Cell reports,
