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The effect of thymopentin treatment on the immune defects in drug addicts with persistent generalized lymphadenopathy and HTLV-III infection was investigated. Thymopentin was administered subcutaneously at two different dose schedules: 50 mg three times a week for 3 weeks (first cycle) and 50 mg/week for 3 months (second cycle). After the first cycle an increased number of OKT4+ lymphocytes and an improvement of PWM-induced blastogenesis and IgG synthesis in vitro was observed. The second cycle was unable to modify the same immune parameters in vitro. The treatment had no effect on the PHA responsiveness and on PHA-induced interleukin 2 production. The significance and the prognostic value of these findings are discussed in terms of the clinical evolution of the syndrome.
W Barcellini, and
P L Meroni, and
D Frasca, and
C Sguotti, and
M O Borghi, and
C Uberti-Foppa, and
P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
June 1986,
Journal of clinical & laboratory immunology,
W Barcellini, and
P L Meroni, and
D Frasca, and
C Sguotti, and
M O Borghi, and
C Uberti-Foppa, and
P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
September 1984,
Bollettino dell'Istituto sieroterapico milanese,
W Barcellini, and
P L Meroni, and
D Frasca, and
C Sguotti, and
M O Borghi, and
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P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
April 1990,
Minerva medica,
W Barcellini, and
P L Meroni, and
D Frasca, and
C Sguotti, and
M O Borghi, and
C Uberti-Foppa, and
P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
January 1984,
Infection,
W Barcellini, and
P L Meroni, and
D Frasca, and
C Sguotti, and
M O Borghi, and
C Uberti-Foppa, and
P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
December 1990,
Anales de medicina interna (Madrid, Spain : 1984),
W Barcellini, and
P L Meroni, and
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C Uberti-Foppa, and
P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
November 1985,
Archives of pathology & laboratory medicine,
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P L Meroni, and
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C Sguotti, and
M O Borghi, and
C Uberti-Foppa, and
P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
January 1986,
AIDS research,
W Barcellini, and
P L Meroni, and
D Frasca, and
C Sguotti, and
M O Borghi, and
C Uberti-Foppa, and
P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
May 1986,
Pathology, research and practice,
W Barcellini, and
P L Meroni, and
D Frasca, and
C Sguotti, and
M O Borghi, and
C Uberti-Foppa, and
P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
June 1985,
Canadian Medical Association journal,
W Barcellini, and
P L Meroni, and
D Frasca, and
C Sguotti, and
M O Borghi, and
C Uberti-Foppa, and
P Buzzetti, and
A Lazzarin, and
G Doria, and
M Moroni
January 1988,
Journal of clinical immunology,
