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We evaluated whether an enteric-coated aspirin formulation showed a "presystemic" component in its antiplatelet effect and if so would spare vascular cyclooxygenase. In six healthy volunteers, 30 to 45 minutes after ingestion of 325 mg enteric-coated aspirin, platelet thromboxane A2 generation was inhibited by about 20% before any drug could be detected in the peripheral venous blood. A further decline in thromboxane A2 generation occurred with appearance of aspirin in blood between 60 and 240 minutes. No presystemic component could be detected after 325 mg aspirin tablets. Ten patients undergoing saphenectomy received 325 mg of either aspirin tablet or enteric-coated aspirin; 12 hours later platelet thromboxane A2 and peripheral vascular prostacyclin generation were significantly reduced by 98% and 58%, respectively. The effects of the two aspirin formulations were not different. Aspirin formulations with "presystemic" component in their antiplatelet effect may not necessarily result in sparing of peripheral vascular cyclooxygenase.
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
May 1981,
The New England journal of medicine,
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
January 1981,
The New England journal of medicine,
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
December 1980,
Circulation,
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
October 1987,
The Australian and New Zealand journal of surgery,
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
January 1987,
Advances in prostaglandin, thromboxane, and leukotriene research,
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
July 1993,
Prostaglandins, leukotrienes, and essential fatty acids,
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
April 1993,
The Annals of pharmacotherapy,
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
July 1983,
The Journal of laboratory and clinical medicine,
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
January 1981,
Thrombosis research,
C Cerletti, and
S Marchi, and
D Lauri, and
M Domanin, and
G Lorenzi, and
R Urso, and
E Dejana, and
R Latini, and
G de Gaetano
September 1985,
Thrombosis research,
