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Serum levels of biologically active LH (bLH) and immunoreactive LH (iLH) under basal conditions and in response to the iv injection of 0.1 mg synthetic LRH were measured in a 15-year-old boy with the 46,XX karyotype. LH bioactivity was assessed "in vitro" on mouse Leydig cell preparations, whereas iLH levels were measured by a double antibody RIA technique. High basal levels of both bLH and iLH were shown in the XX male. Following LRH administration, the relative maximum response of LH above basal levels (LH delta %) was higher for iLH than for bLH. Consequently, the LH bioactivity to immunoreactivity (b/i) ratio decreased from basal values. Since a similar decrease in the b/i ratio of LRH-stimulated LH has been observed in patients with Klinefelter's and Turner's syndrome, we can suppose that in the chromosomal disorders of sex differentiation the pituitary gland possesses a lower responsiveness for bLH than the normal pituitary.
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
July 1985,
Acta endocrinologica,
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
January 1989,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
February 1982,
Acta endocrinologica,
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
January 1997,
Journal of endocrinological investigation,
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
February 1983,
Acta endocrinologica,
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
July 1985,
The Journal of urology,
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
June 1985,
Boletin medico del Hospital Infantil de Mexico,
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
June 1980,
Endokrinologie,
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
July 2002,
Cancer genetics and cytogenetics,
M Grandi, and
A Borghi, and
F Vaccari, and
M F Celani
October 2002,
Neurogenetics,
