-transparent.png){kind=logo}
Cultured human cytotrophoblasts synthesize and secrete urokinase-type plasminogen activator (uPA) during the first 24 h of culture, but secretion declines during the subsequent day. In contrast, synthesis and secretion of fibronectin increases during the 2 days of culture. The levels of uPA mRNA parallel the changes in synthesis and secretion of uPA. Treatment of cytotrophoblasts with 8-bromo-cAMP (1.5 mM) transiently raises uPA mRNA levels and uPA secretion. This treatment reduces fibronectin mRNA levels and causes a sustained increase in beta chorionic gonadotropin mRNA content and chorionic gonadotropin secretion. We conclude that a cAMP-mediated process up-regulates uPA expression in cytotrophoblasts. However, the stimulatory effect of the cyclic nucleotide analog on uPA is transient.
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
October 1996,
Experimental cell research,
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
January 2001,
Methods in enzymology,
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
January 1985,
Journal of cellular physiology,
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
January 1997,
American journal of obstetrics and gynecology,
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
January 2001,
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society,
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
January 1982,
Annals of the New York Academy of Sciences,
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
January 2007,
The international journal of biochemistry & cell biology,
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
October 1979,
Thrombosis and haemostasis,
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
April 2009,
Canadian journal of physiology and pharmacology,
J T Queenan, and
L C Kao, and
C E Arboleda, and
A Ulloa-Aguirre, and
T G Golos, and
D B Cines, and
J F Strauss
January 2009,
Scandinavian journal of clinical and laboratory investigation,
